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• W1520734568 abstract "There has been significant interest in understanding how interactions between the host immune system and the gut microbiota regulate intestinal homeostasis. Recent data suggest that the Nod-like receptor (NLR) family of PRRs regulate both the composition of the gut microbiota and innate immune signaling pathways that prevent pathologic intestinal inflammation and tumorigenesis. In this review, we will focus on NLRP6 and NLRP12, two members of the NLR family that have emerged as important players in the maintenance of intestinal homeostasis, and discuss the signaling pathways engaged by these receptors as well as the current models of how these receptors protect against the development of colitis and tumorigenesis." @default.
• W1520734568 created "2016-06-24" @default.
• W1520734568 creator A5032066391 @default.
• W1520734568 date "2014-01-16" @default.
• W1520734568 modified "2023-10-02" @default.
• W1520734568 title "Role of Nlrp6 and Nlrp12 in the maintenance of intestinal homeostasis" @default.
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• W1520734568 doi "https://doi.org/10.1002/eji.201344135" @default.
• W1520734568 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3932540" @default.
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