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- W1520761387 abstract "The measurement of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] in biological samples is of great importance from a medical point of view and as a research tool. An assessment of serum 1,25-(OH)2D3 concentration can be helpful in the diagnosis and treatment of a variety of bone diseases—parathyroid gland dysfunction, malignancies, renal failure, end-organ resistance diseases, and metabolic disorders. It is useful as a research tool in medicine, physiology, and metabolism. Traditional methodologies for 1,25-(OH)2D3 measurement include bioassay, radioimmunoassay, cytoreceptor assay, or radioreceptor assay. Methods for serum metabolite isolation and preparation of stable 1,25-(OH)2D3 receptor (VDR) have greatly improved the use of radioreceptor technology. Also, there have been improvements in radioimmunoassay technology for 1,25-(OH)2D3. Each of these methods has played a valuable role in the characterization of the disorders, however, they rely on complicated preassay strategies to isolate and purify 1,25-(OH)2D3. Advances in the development of monoclonal antibodies (mAb) to VDR and gene reporter systems for the assessment of 1,25-(OH)2D3 action can be utilized as powerful tools for rapid, accurate, and sensitive measurements of 1,25-(OH)2D3. This chapter describes two of the newer approaches for determining 1,25-(OH)2D3 concentrations from small volumes of serum. Neither of these assays requires extensive extraction, bound/free protein separation, or high-performance liquid chromatography because of the highly specific nature of each assay." @default.
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- W1520761387 title "[15] Assay of 1,25-dihydroxyvitamin D3 from serum samples: Use of receptor-binding or enzyme-coupled reporter analysis" @default.
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- W1520761387 doi "https://doi.org/10.1016/s0076-6879(97)82105-2" @default.
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