FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1520761649> ?p ?o ?g. }

• W1520761649 endingPage "17531" @default.
• W1520761649 startingPage "17514" @default.
• W1520761649 abstract "The vacuolar H+ ATPase (V-ATPase) is a proton pump responsible for acidification of cellular microenvironments, an activity exploited by tumors to survive, proliferate and resist to therapy. Despite few observations, the role of V-ATPase in human tumorigenesis remains unclear.We investigated the expression of ATP6V0C, ATP6V0A2, encoding two subunits belonging to the V-ATPase V0 sector and ATP6V1C, ATP6V1G1, ATPT6V1G2, ATP6V1G3, which are part of the V1 sector, in series of adult gliomas and in cancer stem cell-enriched neurospheres isolated from glioblastoma (GBM) patients. ATP6V1G1 expression resulted significantly upregulated in tissues of patients with GBM and correlated with shorter patients' overall survival independent of clinical variables.ATP6V1G1 knockdown in GBM neurospheres hampered sphere-forming ability, induced cell death, and decreased matrix invasion, a phenotype not observed in GBM monolayer cultures. Treating GBM organotypic cultures or neurospheres with the selective V-ATPase inhibitor bafilomycin A1 reproduced the effects of ATP6V1G1 siRNA and strongly suppressed expression of the stem cell markers Nestin, CD133 and transcription factors SALL2 and POU3F2 in neurospheres.These data point to ATP6V1G1 as a novel marker of poor prognosis in GBM patients and identify V-ATPase inhibition as an innovative therapeutic strategy for GBM." @default.
• W1520761649 created "2016-06-24" @default.
• W1520761649 creator A5005608989 @default.
• W1520761649 creator A5007181443 @default.
• W1520761649 creator A5007639428 @default.
• W1520761649 creator A5016969859 @default.
• W1520761649 creator A5037434863 @default.
• W1520761649 creator A5038705314 @default.
• W1520761649 creator A5040774134 @default.
• W1520761649 creator A5056036105 @default.
• W1520761649 creator A5067688250 @default.
• W1520761649 creator A5068374820 @default.
• W1520761649 creator A5068523562 @default.
• W1520761649 creator A5069400409 @default.
• W1520761649 creator A5086461219 @default.
• W1520761649 date "2015-05-22" @default.
• W1520761649 modified "2023-10-08" @default.
• W1520761649 title "The vacuolar H+ ATPase is a novel therapeutic target for glioblastoma" @default.
• W1520761649 cites W1508624047 @default.
• W1520761649 cites W1571111796 @default.
• W1520761649 cites W1603645579 @default.
• W1520761649 cites W1865575659 @default.
• W1520761649 cites W1893588436 @default.
• W1520761649 cites W1971394915 @default.
• W1520761649 cites W1981705266 @default.
• W1520761649 cites W1982599299 @default.
• W1520761649 cites W1984530522 @default.
• W1520761649 cites W1998346364 @default.
• W1520761649 cites W2005142336 @default.
• W1520761649 cites W2008812368 @default.
• W1520761649 cites W2013735638 @default.
• W1520761649 cites W2016913573 @default.
• W1520761649 cites W2017036697 @default.
• W1520761649 cites W2019097500 @default.
• W1520761649 cites W2027113588 @default.
• W1520761649 cites W2036870885 @default.
• W1520761649 cites W2037372496 @default.
• W1520761649 cites W2044728857 @default.
• W1520761649 cites W2046585193 @default.
• W1520761649 cites W2048532873 @default.
• W1520761649 cites W2061369703 @default.
• W1520761649 cites W2065415433 @default.
• W1520761649 cites W2068050569 @default.
• W1520761649 cites W2070444480 @default.
• W1520761649 cites W2077083517 @default.
• W1520761649 cites W2079914139 @default.
• W1520761649 cites W2082318997 @default.
• W1520761649 cites W2084441235 @default.
• W1520761649 cites W2084496264 @default.
• W1520761649 cites W2099040856 @default.
• W1520761649 cites W2107098864 @default.
• W1520761649 cites W2111152582 @default.
• W1520761649 cites W2111607026 @default.
• W1520761649 cites W2112932851 @default.
• W1520761649 cites W2116010306 @default.
• W1520761649 cites W2116458487 @default.
• W1520761649 cites W2126326979 @default.
• W1520761649 cites W2140072179 @default.
• W1520761649 cites W2140163306 @default.
• W1520761649 cites W2157219413 @default.
• W1520761649 cites W2160382843 @default.
• W1520761649 cites W2163073962 @default.
• W1520761649 cites W2166798417 @default.
• W1520761649 cites W2169071938 @default.
• W1520761649 cites W2169913736 @default.
• W1520761649 doi "https://doi.org/10.18632/oncotarget.4239" @default.
• W1520761649 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4627325" @default.
• W1520761649 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26020805" @default.
• W1520761649 hasPublicationYear "2015" @default.
• W1520761649 type Work @default.
• W1520761649 sameAs 1520761649 @default.
• W1520761649 citedByCount "60" @default.
• W1520761649 countsByYear W15207616492015 @default.
• W1520761649 countsByYear W15207616492016 @default.
• W1520761649 countsByYear W15207616492017 @default.
• W1520761649 countsByYear W15207616492018 @default.
• W1520761649 countsByYear W15207616492019 @default.
• W1520761649 countsByYear W15207616492020 @default.
• W1520761649 countsByYear W15207616492021 @default.
• W1520761649 countsByYear W15207616492022 @default.
• W1520761649 countsByYear W15207616492023 @default.
• W1520761649 crossrefType "journal-article" @default.
• W1520761649 hasAuthorship W1520761649A5005608989 @default.
• W1520761649 hasAuthorship W1520761649A5007181443 @default.
• W1520761649 hasAuthorship W1520761649A5007639428 @default.
• W1520761649 hasAuthorship W1520761649A5016969859 @default.
• W1520761649 hasAuthorship W1520761649A5037434863 @default.
• W1520761649 hasAuthorship W1520761649A5038705314 @default.
• W1520761649 hasAuthorship W1520761649A5040774134 @default.
• W1520761649 hasAuthorship W1520761649A5056036105 @default.
• W1520761649 hasAuthorship W1520761649A5067688250 @default.
• W1520761649 hasAuthorship W1520761649A5068374820 @default.
• W1520761649 hasAuthorship W1520761649A5068523562 @default.
• W1520761649 hasAuthorship W1520761649A5069400409 @default.
• W1520761649 hasAuthorship W1520761649A5086461219 @default.
• W1520761649 hasBestOaLocation W15207616491 @default.
• W1520761649 hasConcept C104317684 @default.
• W1520761649 hasConcept C121608353 @default.

• next