FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1520782715> ?p ?o ?g. }

• W1520782715 endingPage "114" @default.
• W1520782715 startingPage "107" @default.
• W1520782715 abstract "Cyclooxygenase-2 (COX-2) is a key inflammatory response molecule, and associated with many immune functions of monocytes/macrophages. Particularly, interferon gamma (IFNgamma)-induced COX-2 expression appears in inflammatory conditions such as viral infection and autoimmune diseases. Recently, statins have been reported to show variable effects on COX-2 expression, and on their cell and species type dependences. Based on the above description, we compared the effect of simvastatin on IFNgamma-induced COX-2 expression in human monocytes versus murine macrophages. In a result, we found that simvastatin suppresses IFNgamma-induced COX-2 expression in human THP-1 monocytes, but rather, potentiates IFNgamma-induced COX-2 expression in murine RAW264.7 macrophages. However, signal transducer and activator of transcription 1/3 (STAT1/3), known as a transcription factor on COX-2 expression, is inactivated by simvastatin in both cells. Our findings showed that simvastatin is likely to suppress IFNgamma-induced COX-2 expression by inhibiting STAT1/3 activation in human THP-1 cells, but not in murine RAW264.7 cells. Thus, we concluded that IFNgamma-induced COX-2 expression is differently regulated by simvastatin depending on species specific mechanism." @default.
• W1520782715 created "2016-06-24" @default.
• W1520782715 creator A5011960125 @default.
• W1520782715 creator A5013412706 @default.
• W1520782715 creator A5028967572 @default.
• W1520782715 creator A5077382159 @default.
• W1520782715 creator A5083458104 @default.
• W1520782715 creator A5088305725 @default.
• W1520782715 creator A5088893064 @default.
• W1520782715 date "2009-01-01" @default.
• W1520782715 modified "2023-09-27" @default.
• W1520782715 title "Simvastatin acts as an inhibitor of interferon gamma-induced cycloxygenase-2 expression in human THP-1 cells, but not in murine RAW264.7 cells" @default.
• W1520782715 cites W1491204404 @default.
• W1520782715 cites W1963913523 @default.
• W1520782715 cites W1972666937 @default.
• W1520782715 cites W1973563363 @default.
• W1520782715 cites W1978307401 @default.
• W1520782715 cites W1997411618 @default.
• W1520782715 cites W2001327092 @default.
• W1520782715 cites W2001615105 @default.
• W1520782715 cites W2002384956 @default.
• W1520782715 cites W2006548349 @default.
• W1520782715 cites W2010936418 @default.
• W1520782715 cites W2013958910 @default.
• W1520782715 cites W2028345556 @default.
• W1520782715 cites W2030006649 @default.
• W1520782715 cites W2032841359 @default.
• W1520782715 cites W2061313641 @default.
• W1520782715 cites W2065601715 @default.
• W1520782715 cites W2075325752 @default.
• W1520782715 cites W2078654057 @default.
• W1520782715 cites W2094499949 @default.
• W1520782715 cites W2099990449 @default.
• W1520782715 cites W2104038610 @default.
• W1520782715 cites W2120087347 @default.
• W1520782715 cites W2125917292 @default.
• W1520782715 cites W2131662040 @default.
• W1520782715 cites W2152000177 @default.
• W1520782715 cites W2159974155 @default.
• W1520782715 cites W2165560542 @default.
• W1520782715 doi "https://doi.org/10.32604/biocell.2009.33.107" @default.
• W1520782715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19886038" @default.
• W1520782715 hasPublicationYear "2009" @default.
• W1520782715 type Work @default.
• W1520782715 sameAs 1520782715 @default.
• W1520782715 citedByCount "14" @default.
• W1520782715 countsByYear W15207827152013 @default.
• W1520782715 countsByYear W15207827152014 @default.
• W1520782715 countsByYear W15207827152015 @default.
• W1520782715 countsByYear W15207827152018 @default.
• W1520782715 countsByYear W15207827152019 @default.
• W1520782715 countsByYear W15207827152020 @default.
• W1520782715 countsByYear W15207827152021 @default.
• W1520782715 countsByYear W15207827152023 @default.
• W1520782715 crossrefType "journal-article" @default.
• W1520782715 hasAuthorship W1520782715A5011960125 @default.
• W1520782715 hasAuthorship W1520782715A5013412706 @default.
• W1520782715 hasAuthorship W1520782715A5028967572 @default.
• W1520782715 hasAuthorship W1520782715A5077382159 @default.
• W1520782715 hasAuthorship W1520782715A5083458104 @default.
• W1520782715 hasAuthorship W1520782715A5088305725 @default.
• W1520782715 hasAuthorship W1520782715A5088893064 @default.
• W1520782715 hasBestOaLocation W15207827151 @default.
• W1520782715 hasConcept C153911025 @default.
• W1520782715 hasConcept C171958077 @default.
• W1520782715 hasConcept C185592680 @default.
• W1520782715 hasConcept C203014093 @default.
• W1520782715 hasConcept C204258353 @default.
• W1520782715 hasConcept C2776178377 @default.
• W1520782715 hasConcept C2776329913 @default.
• W1520782715 hasConcept C2777003663 @default.
• W1520782715 hasConcept C2778923194 @default.
• W1520782715 hasConcept C2780841837 @default.
• W1520782715 hasConcept C502942594 @default.
• W1520782715 hasConcept C54355233 @default.
• W1520782715 hasConcept C62478195 @default.
• W1520782715 hasConcept C81885089 @default.
• W1520782715 hasConcept C86803240 @default.
• W1520782715 hasConcept C8891405 @default.
• W1520782715 hasConcept C95444343 @default.
• W1520782715 hasConcept C98274493 @default.
• W1520782715 hasConceptScore W1520782715C153911025 @default.
• W1520782715 hasConceptScore W1520782715C171958077 @default.
• W1520782715 hasConceptScore W1520782715C185592680 @default.
• W1520782715 hasConceptScore W1520782715C203014093 @default.
• W1520782715 hasConceptScore W1520782715C204258353 @default.
• W1520782715 hasConceptScore W1520782715C2776178377 @default.
• W1520782715 hasConceptScore W1520782715C2776329913 @default.
• W1520782715 hasConceptScore W1520782715C2777003663 @default.
• W1520782715 hasConceptScore W1520782715C2778923194 @default.
• W1520782715 hasConceptScore W1520782715C2780841837 @default.
• W1520782715 hasConceptScore W1520782715C502942594 @default.
• W1520782715 hasConceptScore W1520782715C54355233 @default.
• W1520782715 hasConceptScore W1520782715C62478195 @default.
• W1520782715 hasConceptScore W1520782715C81885089 @default.
• W1520782715 hasConceptScore W1520782715C86803240 @default.
• W1520782715 hasConceptScore W1520782715C8891405 @default.
• W1520782715 hasConceptScore W1520782715C95444343 @default.

• next