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- W152078276 abstract "Premature ovarian failure (POF) is commonly defined as the cessation of ovarian function accompanied by gonadotropin measurements in the menopausal range before age 40. This entity occurs in roughly 1% of women. Although for many patients, the etiology of their gonadal failure remains an enigma, others demonstrate convincing chromosomal, infectious, autoimmune, or iatrogenic risk factors. Elevated serum gonadotropin levels may reflect a total depletion of ovarian follicles in some patients; in others, increased follicle stimulating hormone (FSH) and luteinizing hormone (LH) may signify the resistance of primitive follicles to stimulation. In either case, major repercussions of premature ovarian failure can stem from both diminished ovarian estrogen production and the associated disease states responsible for the condition. Clinical sequelae from occult gonadal failure range in severity, encompassing infertility, irregular menses, and moderately elevated gonadotropin levels, to frank ovarian endocrine failure with hypoestrogenemia and amenorrhea Similar to the physiologic menopause, the rapidity of each woman’ s progress through this spectrum of ovarian demise is highly variable." @default.
- W152078276 created "2016-06-24" @default.
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- W152078276 date "1999-01-01" @default.
- W152078276 modified "2023-10-17" @default.
- W152078276 title "Premature Ovarian Failure and Surgical Menopause" @default.
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- W152078276 doi "https://doi.org/10.1007/978-1-59259-246-3_8" @default.
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