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- W1520782770 abstract "Previous studies have demonstrated that matrix metalloproteinase-2 (MMP-2) is involved in cleaving and activating several non-extracellular matrix substrates as well such as transforming growth factor-beta (TGF-β) that participate in the accumulation of mesanigal extracellular matrix leading to glomerulosclerosis during diabetes-induced renal disease. However, the mechanism by which MMP-2 becomes activated remains unclear. Therefore, the aim of the present study was to compare the effects of hyperglycemia and cyclic stretching (FlexCell System) on the expression of MMP-2 and TGF-β in cultured rat mesangial cells (MCs). MCs were seeded on 6-well flex-bottom plates and cultured in normal glucose (NG) medium. After 24 hrs, the wells in each plate were equally divided into NG and high glucose (HG). The next day, MCs were exposed to cyclic stretching for 18 hrs. We did not observe any differences in MMP-2 and TGF-β expression between static NG- and HG-treated MCs. However, exposure to cyclic stretching significantly increased the expression of MMP-2 and TGF-β protein in both NG and HG-treated MCs in comparison to static-treated MCs. Moreover, MMP-2 activity was markedly increased in response to cyclic stretching regardless of whether hyperglycemia was present. These data indicate that the upregulation of MMP-2 and TGF-β in MCs is primarily due to cyclic stretching rather than hyperglycemia." @default.
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- W1520782770 date "2014-04-01" @default.
- W1520782770 modified "2023-10-16" @default.
- W1520782770 title "Effects of hyperglycemia and cyclic stretching on MMP‐2 and TGF‐β in rat mesangial cells (689.8)" @default.
- W1520782770 doi "https://doi.org/10.1096/fasebj.28.1_supplement.689.8" @default.
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