FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1520784224> ?p ?o ?g. }

• W1520784224 endingPage "4576" @default.
• W1520784224 startingPage "4566" @default.
• W1520784224 abstract "Thyrotropin-releasing hormone receptor (TRHR) has already been cloned in mammals wherethyrotropin-releasing hormone (TRH) is known to act as a powerful stimulator of thyroid-stimulating hormone (TSH) secretion. The TRH receptor of amphibians has not yet been characterized, although TRH is specifically important in the adaptation of skin color to environmental changes via the secretion of alpha-melanocyte-stimulating hormone (alpha-MSH). Using a dege-nerate PCR strategy, we report on the isolation of three distinct cDNA species encoding TRHR from the brain of Xenopus laevis. We have designated these as xTRHR1, xTRHR2 and xTRHR3. Analysis of the predicted amino acid sequences revealed that the three Xenopus TRHRs are only 54-62% identical and contain all the highly conserved residues constituting the TRH binding pocket. Amino acid sequences and phylogenetic analysis revealed that xTRHR1 is a member of TRHR subfamily 1 and xTRHR2 belongs to subfamily 2, while xTRHR3 is a new TRHR subtype awaiting discovery in other animal species. The three Xeno-pus TRHRs have distinct patterns of expression. xTRHR3 was abundant in the brain and much scarcer in the peripheral tissues, whereas xTRHR1 was found mainly in the stomach and xTRHR2 in the heart. The Xenopus TRHR subtype 1 was found specifically in the intestine, lung and urinary bladder. These observations suggest that the three xTRHRs each have specific functions that remain to be elucidated. Expression in Xenopus oocytes and HEK-293 cells indicates that the three Xenopus TRHRs are fully functional and are coupled to the inositol phosphate/calcium pathway. Interestingly, activation of xTRHR3 required larger concentrations of TRH compared with the other two receptors, suggesting marked differences in receptor binding, coupling or regulation." @default.
• W1520784224 created "2016-06-24" @default.
• W1520784224 creator A5001992591 @default.
• W1520784224 creator A5003299717 @default.
• W1520784224 creator A5009146419 @default.
• W1520784224 creator A5041198374 @default.
• W1520784224 creator A5086683190 @default.
• W1520784224 date "2002-09-01" @default.
• W1520784224 modified "2023-10-18" @default.
• W1520784224 title "Characterization and functional expression of cDNAs encoding thyrotropin-releasing hormone receptor fromXenopus laevis" @default.
• W1520784224 cites W1482038898 @default.
• W1520784224 cites W1538830561 @default.
• W1520784224 cites W1548575930 @default.
• W1520784224 cites W1563318056 @default.
• W1520784224 cites W1749033312 @default.
• W1520784224 cites W1821817384 @default.
• W1520784224 cites W1964342371 @default.
• W1520784224 cites W1970904468 @default.
• W1520784224 cites W1975304761 @default.
• W1520784224 cites W1985759482 @default.
• W1520784224 cites W1989684809 @default.
• W1520784224 cites W1994641534 @default.
• W1520784224 cites W2002423460 @default.
• W1520784224 cites W2004077337 @default.
• W1520784224 cites W2009375029 @default.
• W1520784224 cites W2010677283 @default.
• W1520784224 cites W2018892681 @default.
• W1520784224 cites W2022397230 @default.
• W1520784224 cites W2022797453 @default.
• W1520784224 cites W2027232034 @default.
• W1520784224 cites W2035103640 @default.
• W1520784224 cites W2036752614 @default.
• W1520784224 cites W2039412078 @default.
• W1520784224 cites W2050367027 @default.
• W1520784224 cites W2053654135 @default.
• W1520784224 cites W2059945403 @default.
• W1520784224 cites W2067674574 @default.
• W1520784224 cites W2069089926 @default.
• W1520784224 cites W2070495498 @default.
• W1520784224 cites W2072527501 @default.
• W1520784224 cites W2080899899 @default.
• W1520784224 cites W2086040701 @default.
• W1520784224 cites W2087766008 @default.
• W1520784224 cites W2093035480 @default.
• W1520784224 cites W2093997127 @default.
• W1520784224 cites W2097382368 @default.
• W1520784224 cites W2114793335 @default.
• W1520784224 cites W2130799585 @default.
• W1520784224 cites W2136067737 @default.
• W1520784224 cites W2140945131 @default.
• W1520784224 cites W2148830596 @default.
• W1520784224 cites W2153541835 @default.
• W1520784224 cites W2398104265 @default.
• W1520784224 cites W4237081648 @default.
• W1520784224 doi "https://doi.org/10.1046/j.1432-1033.2002.03152.x" @default.
• W1520784224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12230569" @default.
• W1520784224 hasPublicationYear "2002" @default.
• W1520784224 type Work @default.
• W1520784224 sameAs 1520784224 @default.
• W1520784224 citedByCount "24" @default.
• W1520784224 countsByYear W15207842242013 @default.
• W1520784224 countsByYear W15207842242015 @default.
• W1520784224 countsByYear W15207842242018 @default.
• W1520784224 countsByYear W15207842242020 @default.
• W1520784224 countsByYear W15207842242021 @default.
• W1520784224 crossrefType "journal-article" @default.
• W1520784224 hasAuthorship W1520784224A5001992591 @default.
• W1520784224 hasAuthorship W1520784224A5003299717 @default.
• W1520784224 hasAuthorship W1520784224A5009146419 @default.
• W1520784224 hasAuthorship W1520784224A5041198374 @default.
• W1520784224 hasAuthorship W1520784224A5086683190 @default.
• W1520784224 hasBestOaLocation W15207842241 @default.
• W1520784224 hasConcept C104317684 @default.
• W1520784224 hasConcept C121608353 @default.
• W1520784224 hasConcept C133603901 @default.
• W1520784224 hasConcept C153911025 @default.
• W1520784224 hasConcept C167625842 @default.
• W1520784224 hasConcept C170493617 @default.
• W1520784224 hasConcept C187882448 @default.
• W1520784224 hasConcept C23589133 @default.
• W1520784224 hasConcept C2776216936 @default.
• W1520784224 hasConcept C2779535977 @default.
• W1520784224 hasConcept C50929876 @default.
• W1520784224 hasConcept C530470458 @default.
• W1520784224 hasConcept C54355233 @default.
• W1520784224 hasConcept C55493867 @default.
• W1520784224 hasConcept C71315377 @default.
• W1520784224 hasConcept C86803240 @default.
• W1520784224 hasConceptScore W1520784224C104317684 @default.
• W1520784224 hasConceptScore W1520784224C121608353 @default.
• W1520784224 hasConceptScore W1520784224C133603901 @default.
• W1520784224 hasConceptScore W1520784224C153911025 @default.
• W1520784224 hasConceptScore W1520784224C167625842 @default.
• W1520784224 hasConceptScore W1520784224C170493617 @default.
• W1520784224 hasConceptScore W1520784224C187882448 @default.
• W1520784224 hasConceptScore W1520784224C23589133 @default.
• W1520784224 hasConceptScore W1520784224C2776216936 @default.
• W1520784224 hasConceptScore W1520784224C2779535977 @default.

• next