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- W1520792648 startingPage "3652" @default.
- W1520792648 abstract "AT11-2 is an Abelson virus-transformed B precursor cell line which is capable of differentiating Ig- from mu+ cells via functional recombination of VH segments to preexisting DJH complexes. We describe here that after a mu+ subclone (VDJ+/DJ) generated from Ig- AT11-2 (DJ/DJ) cells by in vitro functional VH to DJH recombination subsequently lost mu-chain expression either by the recombination of a pseudo VH segment to the VHDJH+ allele or by the deletion of VHDJH+ allele, a novel productive joining of VH segments to the preexisting DJH complex occurred. These results indicated that VH to VHDJH rearrangement was not suppressed in mu-chain producing cells and that the DJH complexes still remained active in the recombination to VH segments after the loss of mu-chain expression. Our results may also suggest that VH to DJH rearrangement, but not VH to VHDJH rearrangement, is suppressed in mu-chain producing cells to maintain allelic exclusion. Our cell differentiation system should continue to be valuable for elucidating the mechanism of suppression and associated implications regarding allelic exclusion." @default.
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- W1520792648 date "1989-05-15" @default.
- W1520792648 modified "2023-10-12" @default.
- W1520792648 title "The DJH complex remains active in recombination to VH segments after the loss of mu-chain expression in mu-positive pre-B cells." @default.
- W1520792648 doi "https://doi.org/10.4049/jimmunol.142.10.3652" @default.
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