Matches in SemOpenAlex for { <https://semopenalex.org/work/W1520852884> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W1520852884 abstract "Abstract : 14. ABSTRACT Homeobox transcription factor Six1 has been associated with tumorigenesis and metastasis in a number of organ systems and has been implicated in proliferation, survival, and migration during normal development. Our research is aimed at utilizing mouse models to understand in the role of Six1 in the onset and progression of breast cancer. Most significantly, we have determined that Six1 is sufficient to induce tumor formation in the mammary glands of mice genetically engineered to inducibly overexpress the gene. The latency for tumor formation is between 12-24 months and the tumors that arise in these animals are very aggressive and have morphological features of an epithelial to mesenchymal transition (EMT), a phenomenon that has recently been suggested to contribute to metastasis, and stem cell origin. Molecular analysis of these tumors has revealed activation of the Wnt signaling pathway, a pathway implicated in maintaining EMT and a stem cell fate that may contribute to tumorigenesis. Additionally, we have discovered that our inducible mouse model allows for leaky transcription of Six1 in the uninduced state. Interestingly, animals from this group acquire tumors at an increased frequency compared to those animals that are induced to express Six1, suggesting that even low levels of Six1 are capable, and may even be more efficient at initiating tumorigenesis compared to higher Six1 levels. These compelling results in combination with similar findings in our experiments involving Six1 in combination with PyMT have led to more studies to dissect the role of Six1 levels and its cofactors in breast cancer initiation and progression." @default.
- W1520852884 created "2016-06-24" @default.
- W1520852884 creator A5012640597 @default.
- W1520852884 date "2007-04-01" @default.
- W1520852884 modified "2023-09-25" @default.
- W1520852884 title "In Vivo Role of Six1 in Mammary Gland Tumorigenesis" @default.
- W1520852884 cites W1998767677 @default.
- W1520852884 cites W2001199164 @default.
- W1520852884 cites W2011399707 @default.
- W1520852884 cites W2016592525 @default.
- W1520852884 cites W2019357978 @default.
- W1520852884 cites W2022297771 @default.
- W1520852884 cites W2045066549 @default.
- W1520852884 cites W2059907870 @default.
- W1520852884 cites W2065915956 @default.
- W1520852884 cites W2145805228 @default.
- W1520852884 doi "https://doi.org/10.21236/ada469764" @default.
- W1520852884 hasPublicationYear "2007" @default.
- W1520852884 type Work @default.
- W1520852884 sameAs 1520852884 @default.
- W1520852884 citedByCount "0" @default.
- W1520852884 crossrefType "report" @default.
- W1520852884 hasAuthorship W1520852884A5012640597 @default.
- W1520852884 hasConcept C121608353 @default.
- W1520852884 hasConcept C150903083 @default.
- W1520852884 hasConcept C207001950 @default.
- W1520852884 hasConcept C2778001805 @default.
- W1520852884 hasConcept C502942594 @default.
- W1520852884 hasConcept C530470458 @default.
- W1520852884 hasConcept C54355233 @default.
- W1520852884 hasConcept C555283112 @default.
- W1520852884 hasConcept C86803240 @default.
- W1520852884 hasConcept C95444343 @default.
- W1520852884 hasConceptScore W1520852884C121608353 @default.
- W1520852884 hasConceptScore W1520852884C150903083 @default.
- W1520852884 hasConceptScore W1520852884C207001950 @default.
- W1520852884 hasConceptScore W1520852884C2778001805 @default.
- W1520852884 hasConceptScore W1520852884C502942594 @default.
- W1520852884 hasConceptScore W1520852884C530470458 @default.
- W1520852884 hasConceptScore W1520852884C54355233 @default.
- W1520852884 hasConceptScore W1520852884C555283112 @default.
- W1520852884 hasConceptScore W1520852884C86803240 @default.
- W1520852884 hasConceptScore W1520852884C95444343 @default.
- W1520852884 hasLocation W15208528841 @default.
- W1520852884 hasOpenAccess W1520852884 @default.
- W1520852884 hasPrimaryLocation W15208528841 @default.
- W1520852884 hasRelatedWork W1588169769 @default.
- W1520852884 hasRelatedWork W1733545086 @default.
- W1520852884 hasRelatedWork W1974628872 @default.
- W1520852884 hasRelatedWork W2040526386 @default.
- W1520852884 hasRelatedWork W2056818511 @default.
- W1520852884 hasRelatedWork W2063889984 @default.
- W1520852884 hasRelatedWork W2110689645 @default.
- W1520852884 hasRelatedWork W273209214 @default.
- W1520852884 hasRelatedWork W3001620958 @default.
- W1520852884 hasRelatedWork W4282939817 @default.
- W1520852884 isParatext "false" @default.
- W1520852884 isRetracted "false" @default.
- W1520852884 magId "1520852884" @default.
- W1520852884 workType "report" @default.