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- W1520853869 abstract "Introduction The objective is to show how disease and clinical trial modeling can be applied to estimate the success probability, duration and cost that resulting from a certain trial design or from similar decisions.Methods Multidisplinar team has participated in the construction of the general simulation model of clinical trials. This model is constructed splitting the whole process into two main parts. The first part represents the recruitment sub-model aiming at estimating the time and the number of included patients. The second part is based on the follow-up sub-model represented by disease progression.Results The model is applied to retrospective clinical trial.Conclusion Simulation modelling will optimise clinical trials whenever information from different disciplines, such as clinics, statistics, economics and informatics is integrated and used properly.Keywords:clinical trials;disease;modelling and simulation;optimal design;net benefit" @default.
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- W1520853869 date "2014-09-29" @default.
- W1520853869 modified "2023-09-25" @default.
- W1520853869 title "Disease and Clinical Trial Modeling" @default.
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- W1520853869 doi "https://doi.org/10.1002/9781118445112.stat04122" @default.
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