FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1520868492> ?p ?o ?g. }

• W1520868492 endingPage "917" @default.
• W1520868492 startingPage "909" @default.
• W1520868492 abstract "The p36/LACK antigen from Leishmania, an analogue of the receptor for activated protein kinase C (PKC), induces high levels of protection against parasite infection in the BALB/c mouse model. This protection is more than twice as high as that elicited by major parasite antigens such as soluble Leishmania antigen or the main surface protease gp63. We have cloned and purified p36/LACK from Leishmania infantum, the causative agent of visceral leishmaniasis in Europe. This protein belongs to the large family of WD 40 repeat proteins confined to eukaryotes and involved in numerous regulatory functions. Differential solubilization and immunofluorescence experiments indicate that p36/LACK is present close to the kinetoplast disc in the cell cytoplasm, probably bound to multiprotein complexes but not to membrane structures. These complexes probably also include cytoplasm PKC isoforms. The use of a genetically-encoded peptide library indicates that p36/LACK binds sequences present in several proteins involved in DNA replication and RNA synthesis. The recognition and binding sequences present in vacuolar proteins and at the beta-chain of major histocompatability complex (MHC) class II suggest the involvement of this regulatory protein in the early mechanisms triggering the protective immune response of the host against the parasite infection." @default.
• W1520868492 created "2016-06-24" @default.
• W1520868492 creator A5016314743 @default.
• W1520868492 creator A5035987755 @default.
• W1520868492 creator A5049040642 @default.
• W1520868492 creator A5061297876 @default.
• W1520868492 date "1999-02-01" @default.
• W1520868492 modified "2023-10-17" @default.
• W1520868492 title "Molecular cloning, cell localization and binding affinity to DNA replication proteins of the p36/LACK protective antigen from Leishmania infantum" @default.
• W1520868492 cites W1493993200 @default.
• W1520868492 cites W1546177735 @default.
• W1520868492 cites W1555419656 @default.
• W1520868492 cites W1670114215 @default.
• W1520868492 cites W1946039171 @default.
• W1520868492 cites W1972922050 @default.
• W1520868492 cites W1973046803 @default.
• W1520868492 cites W1976045232 @default.
• W1520868492 cites W1999236460 @default.
• W1520868492 cites W2006319694 @default.
• W1520868492 cites W2010155234 @default.
• W1520868492 cites W2010649076 @default.
• W1520868492 cites W2013258420 @default.
• W1520868492 cites W2032806769 @default.
• W1520868492 cites W2034621133 @default.
• W1520868492 cites W2041556575 @default.
• W1520868492 cites W2052095708 @default.
• W1520868492 cites W2060098125 @default.
• W1520868492 cites W2080796174 @default.
• W1520868492 cites W2084429764 @default.
• W1520868492 cites W2088256755 @default.
• W1520868492 cites W2100837269 @default.
• W1520868492 cites W2105439133 @default.
• W1520868492 cites W2110671512 @default.
• W1520868492 cites W2117451755 @default.
• W1520868492 cites W2127671332 @default.
• W1520868492 cites W2138823732 @default.
• W1520868492 cites W2139144899 @default.
• W1520868492 cites W2162605464 @default.
• W1520868492 cites W2163319734 @default.
• W1520868492 cites W2166103316 @default.
• W1520868492 cites W2168930459 @default.
• W1520868492 cites W2319440795 @default.
• W1520868492 cites W2419428462 @default.
• W1520868492 doi "https://doi.org/10.1046/j.1432-1327.1999.00122.x" @default.
• W1520868492 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10092881" @default.
• W1520868492 hasPublicationYear "1999" @default.
• W1520868492 type Work @default.
• W1520868492 sameAs 1520868492 @default.
• W1520868492 citedByCount "49" @default.
• W1520868492 countsByYear W15208684922012 @default.
• W1520868492 countsByYear W15208684922013 @default.
• W1520868492 countsByYear W15208684922014 @default.
• W1520868492 countsByYear W15208684922015 @default.
• W1520868492 countsByYear W15208684922016 @default.
• W1520868492 countsByYear W15208684922018 @default.
• W1520868492 countsByYear W15208684922019 @default.
• W1520868492 countsByYear W15208684922021 @default.
• W1520868492 countsByYear W15208684922022 @default.
• W1520868492 countsByYear W15208684922023 @default.
• W1520868492 crossrefType "journal-article" @default.
• W1520868492 hasAuthorship W1520868492A5016314743 @default.
• W1520868492 hasAuthorship W1520868492A5035987755 @default.
• W1520868492 hasAuthorship W1520868492A5049040642 @default.
• W1520868492 hasAuthorship W1520868492A5061297876 @default.
• W1520868492 hasConcept C136764020 @default.
• W1520868492 hasConcept C147483822 @default.
• W1520868492 hasConcept C153911025 @default.
• W1520868492 hasConcept C159047783 @default.
• W1520868492 hasConcept C190062978 @default.
• W1520868492 hasConcept C2776555147 @default.
• W1520868492 hasConcept C2778689377 @default.
• W1520868492 hasConcept C2781092759 @default.
• W1520868492 hasConcept C2781257258 @default.
• W1520868492 hasConcept C41008148 @default.
• W1520868492 hasConcept C54355233 @default.
• W1520868492 hasConcept C71928629 @default.
• W1520868492 hasConcept C86803240 @default.
• W1520868492 hasConcept C95444343 @default.
• W1520868492 hasConceptScore W1520868492C136764020 @default.
• W1520868492 hasConceptScore W1520868492C147483822 @default.
• W1520868492 hasConceptScore W1520868492C153911025 @default.
• W1520868492 hasConceptScore W1520868492C159047783 @default.
• W1520868492 hasConceptScore W1520868492C190062978 @default.
• W1520868492 hasConceptScore W1520868492C2776555147 @default.
• W1520868492 hasConceptScore W1520868492C2778689377 @default.
• W1520868492 hasConceptScore W1520868492C2781092759 @default.
• W1520868492 hasConceptScore W1520868492C2781257258 @default.
• W1520868492 hasConceptScore W1520868492C41008148 @default.
• W1520868492 hasConceptScore W1520868492C54355233 @default.
• W1520868492 hasConceptScore W1520868492C71928629 @default.
• W1520868492 hasConceptScore W1520868492C86803240 @default.
• W1520868492 hasConceptScore W1520868492C95444343 @default.
• W1520868492 hasIssue "3" @default.
• W1520868492 hasLocation W15208684921 @default.
• W1520868492 hasLocation W15208684922 @default.
• W1520868492 hasOpenAccess W1520868492 @default.
• W1520868492 hasPrimaryLocation W15208684921 @default.
• W1520868492 hasRelatedWork W2063931411 @default.

• next