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- W1520881302 abstract "This chapter discusses the structure of acid sensing ionic channels (ASICs), their response profiles to acid, localization in a subset of sensory neurons, possible roles in mediating pathological pain, and results from knockout experiments. ASICs are a family of cation channels that are expressed in many types of sensory neurons. All ASICs are permeable to Na+; some also conduct K+ and Ca2+. ASIC1 and ASIC3 are highly acid sensitive and open transiently when the extracellular pH drops only slightly below neutral. ASIC activity is modulated by neuropeptides, extracellular Ca2+, associated proteins, and protein phosphorylation. Since the cloning of the ASICs, a wealth of data regarding biophysical properties, modulators, and expression patterns of ASICs have been accumulated. ASICs with varying subunit combinations are present in half of the sensory neurons examined. Both the knockout of ASIC genes and pharmacological block of ASICs result in impaired H+‐gated inward currents in sensory neurons. Thus, ASICs appear an important component of the acid response mechanism of sensory neurons." @default.
- W1520881302 created "2016-06-24" @default.
- W1520881302 creator A5046273802 @default.
- W1520881302 creator A5047821411 @default.
- W1520881302 date "2006-01-01" @default.
- W1520881302 modified "2023-10-14" @default.
- W1520881302 title "Chapter 8 Acid Sensing Ionic Channels" @default.
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