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- W1520930154 abstract "Treatment with phenobarbital of rats which are genetically selected results in a greater than 10-fold increase in nicotinamide-adenine dinucleotide (NAD)-dependent aldehyde dehydrogenase present in the supernatant but not the mitochondrial fraction of liver. This effect represents one of only a few known cases where intrastrain differences in a drug-induced increase in enzyme activity is genetically controlled. The kinetic characteristics of the enzyme from phenobarbital-treated rats are the same, regardless of whether or not the enzyme activity in the liver is increased. It is also demonstrated that rat liver supernatant contains a second NAD-dependent aldehyde dehydrogenase which (a) is resistant to induction by phenobarbital; (b) oxidizes p-carboxybenzaldehyde; (c) is relatively uninhibited by disulfiram; (d) has a heat stability different from the inducible enzyme." @default.
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- W1520930154 date "1972-11-01" @default.
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- W1520930154 title "Genetic Influence upon Phenobarbital-induced Increase in Rat Liver Supernatant Aldehyde Dehydrogenase Activity" @default.
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- W1520930154 doi "https://doi.org/10.1016/s0021-9258(19)44618-8" @default.
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