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• W1520953463 startingPage "476" @default.
• W1520953463 abstract "We have previously demonstrated that genetic ablation of cationic amino acid transporter 2 (Cat2) significantly inhibits nitric oxide (NO) production by inducible nitric oxide synthase (iNOS) in activated macrophages. Here we report that iNOS activity is impaired by 84% in activated Cat2-deficient astrocytes. Cat2 ablation appears to reduce astrocyte NO synthesis by decreasing the uptake of the sole precursor, arginine, as well as by reducing the expression of iNOS following activation. Excessive or dysregulated NO production by activated astrocytes and other CNS cell types has been implicated in the pathogenesis of neurological disorders. Our results support the idea that manipulation of CAT2 transporter function might be useful for the therapeutic modulation of iNOS activity." @default.
• W1520953463 created "2016-06-24" @default.
• W1520953463 creator A5020501904 @default.
• W1520953463 creator A5067237562 @default.
• W1520953463 creator A5069815937 @default.
• W1520953463 date "2003-03-19" @default.
• W1520953463 modified "2023-09-28" @default.
• W1520953463 title "CAT2 arginine transporter deficiency significantly reduces iNOS-mediated NO production in astrocytes" @default.
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• W1520953463 doi "https://doi.org/10.1046/j.1471-4159.2003.01695.x" @default.
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