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- W1520956822 abstract "[25-R] 3β,7α-Dihydroxy-[5a,6α-3 H2]-5α-cholestanoic acid was prepared, purified and 0.34 mg was administered intraperitoneally as the potassium salt to each of three adult male rats with cannulated bile ducts. Bile collected in the first 24 h, containing 97% of the administered 3 H was hydrolysed and the free bile acids were separated by acetic acid partition chromatography. Of the chromatographed tritium 58% was associated with allochenodeoxycholic acid and 14% with its 3β-isomer; only 5β of the 3 H was found in allocholic acid and 1% with its 3β-isomer. Less than 5% of the tritium appeared in fractions associated with the substrate or more polar unidentified materials. Thus, this dihydroxy-5α-cholestanoic acid is metabolized in the rat primarily to dihydroxy-5acholanic acids, comparable to the metabolism of 3α,7α-dihydroxy-5|3-cholestanoic acid in man." @default.
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- W1520956822 date "1975-04-01" @default.
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- W1520956822 title "Bile acids" @default.
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- W1520956822 doi "https://doi.org/10.1016/0005-2760(75)90068-5" @default.
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