Matches in SemOpenAlex for { <https://semopenalex.org/work/W1520968512> ?p ?o ?g. }
- W1520968512 endingPage "354" @default.
- W1520968512 startingPage "347" @default.
- W1520968512 abstract "Thyroid hormones are required for vertebrate development, and disruption of the thyroid system in developing embryos can result in a large range of morphologic and physiologic changes, including in the eye and retina. In this study, our anatomic analyses following low-dose, chronic thyroid inhibition reveal that both methimazole (MMI) exposure and rearing temperature affect eye development in a time- and temperature-dependent fashion. Maximal sensitivity to MMI for external eye development occurred at 65 hr postfertilization (hpf) for zebrafish reared at 28°C, and at 69 hpf for those reared at 31°C. Changes in eye diameter corresponded to changes in thickness of two inner retinal layers: the ganglion cell layer and the inner plexiform layer, with irreversible MMI-induced decreases in layer thickness observed in larvae treated with MMI until 66 hpf at 28°C. We infer that maximal sensitivity to MMI between 65 and 66 hpf at 28°C indicates a critical period of thyroid-dependent eye and retinal development. Furthermore, our results support previous work that shows spontaneous escape from MMI-induced effects potentially due to embryonic compensatory actions, as our data show that embryos treated beyond the critical period generally resemble controls." @default.
- W1520968512 created "2016-06-24" @default.
- W1520968512 creator A5024778277 @default.
- W1520968512 creator A5024788821 @default.
- W1520968512 date "2014-09-23" @default.
- W1520968512 modified "2023-09-30" @default.
- W1520968512 title "Effects of Low-Dose Embryonic Thyroid Disruption and Rearing Temperature on the Development of the Eye and Retina in Zebrafish" @default.
- W1520968512 cites W1495400959 @default.
- W1520968512 cites W1573386528 @default.
- W1520968512 cites W1668629894 @default.
- W1520968512 cites W1984503539 @default.
- W1520968512 cites W1988819553 @default.
- W1520968512 cites W1990355284 @default.
- W1520968512 cites W1993618816 @default.
- W1520968512 cites W1994713664 @default.
- W1520968512 cites W1999305886 @default.
- W1520968512 cites W2000915541 @default.
- W1520968512 cites W2003070275 @default.
- W1520968512 cites W2007870279 @default.
- W1520968512 cites W2015260011 @default.
- W1520968512 cites W2027113336 @default.
- W1520968512 cites W2035249417 @default.
- W1520968512 cites W2038487944 @default.
- W1520968512 cites W2038915039 @default.
- W1520968512 cites W2051786885 @default.
- W1520968512 cites W2058769130 @default.
- W1520968512 cites W2068607454 @default.
- W1520968512 cites W2072012875 @default.
- W1520968512 cites W2075512798 @default.
- W1520968512 cites W2077095632 @default.
- W1520968512 cites W2082055613 @default.
- W1520968512 cites W2083101606 @default.
- W1520968512 cites W2091084506 @default.
- W1520968512 cites W2099545629 @default.
- W1520968512 cites W2113540542 @default.
- W1520968512 cites W2115582509 @default.
- W1520968512 cites W2120035631 @default.
- W1520968512 cites W2120574535 @default.
- W1520968512 cites W2125349610 @default.
- W1520968512 cites W2131577885 @default.
- W1520968512 cites W2141293611 @default.
- W1520968512 cites W2142987588 @default.
- W1520968512 cites W2149166067 @default.
- W1520968512 cites W2169249307 @default.
- W1520968512 doi "https://doi.org/10.1002/bdrb.21118" @default.
- W1520968512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25250784" @default.
- W1520968512 hasPublicationYear "2014" @default.
- W1520968512 type Work @default.
- W1520968512 sameAs 1520968512 @default.
- W1520968512 citedByCount "29" @default.
- W1520968512 countsByYear W15209685122016 @default.
- W1520968512 countsByYear W15209685122017 @default.
- W1520968512 countsByYear W15209685122018 @default.
- W1520968512 countsByYear W15209685122019 @default.
- W1520968512 countsByYear W15209685122020 @default.
- W1520968512 countsByYear W15209685122021 @default.
- W1520968512 countsByYear W15209685122022 @default.
- W1520968512 countsByYear W15209685122023 @default.
- W1520968512 crossrefType "journal-article" @default.
- W1520968512 hasAuthorship W1520968512A5024778277 @default.
- W1520968512 hasAuthorship W1520968512A5024788821 @default.
- W1520968512 hasConcept C104317684 @default.
- W1520968512 hasConcept C105702510 @default.
- W1520968512 hasConcept C114696181 @default.
- W1520968512 hasConcept C126322002 @default.
- W1520968512 hasConcept C127716648 @default.
- W1520968512 hasConcept C134018914 @default.
- W1520968512 hasConcept C169760540 @default.
- W1520968512 hasConcept C196843134 @default.
- W1520968512 hasConcept C2776878037 @default.
- W1520968512 hasConcept C2777093970 @default.
- W1520968512 hasConcept C2780188069 @default.
- W1520968512 hasConcept C2780827179 @default.
- W1520968512 hasConcept C2781099447 @default.
- W1520968512 hasConcept C2781334511 @default.
- W1520968512 hasConcept C526584372 @default.
- W1520968512 hasConcept C54355233 @default.
- W1520968512 hasConcept C55493867 @default.
- W1520968512 hasConcept C71315377 @default.
- W1520968512 hasConcept C71924100 @default.
- W1520968512 hasConcept C86803240 @default.
- W1520968512 hasConcept C87073359 @default.
- W1520968512 hasConcept C95444343 @default.
- W1520968512 hasConceptScore W1520968512C104317684 @default.
- W1520968512 hasConceptScore W1520968512C105702510 @default.
- W1520968512 hasConceptScore W1520968512C114696181 @default.
- W1520968512 hasConceptScore W1520968512C126322002 @default.
- W1520968512 hasConceptScore W1520968512C127716648 @default.
- W1520968512 hasConceptScore W1520968512C134018914 @default.
- W1520968512 hasConceptScore W1520968512C169760540 @default.
- W1520968512 hasConceptScore W1520968512C196843134 @default.
- W1520968512 hasConceptScore W1520968512C2776878037 @default.
- W1520968512 hasConceptScore W1520968512C2777093970 @default.
- W1520968512 hasConceptScore W1520968512C2780188069 @default.
- W1520968512 hasConceptScore W1520968512C2780827179 @default.
- W1520968512 hasConceptScore W1520968512C2781099447 @default.
- W1520968512 hasConceptScore W1520968512C2781334511 @default.
- W1520968512 hasConceptScore W1520968512C526584372 @default.