Matches in SemOpenAlex for { <https://semopenalex.org/work/W152104336> ?p ?o ?g. }
Showing items 1 to 46 of
46
with 100 items per page.
- W152104336 abstract "We have provided evidence in support of the role of central cholinergic neurons in aspects drug abuse. This study was designed to determine whether a use-dependent nicotinic antagonist bis (2,2,6,6-tetramethyl-4-piperidinyl) sebacate (BTMPS) could block a characteristic withdrawal response to cocaine. Wistar rats (300–325 g) were divided into 3 groups. Over 5 days one (control) group received a daily regimen that consisted of an i.p. injection of saline followed 10 min later by a second saline injection. The other two groups received the following cocaine regimen: 10 mg/kg, i.p. on Days 1, 2 and 3 and 20 mg/kg on Days 4 and 5. Each cocaine injection was preceded 10 min earlier by either a saline injection, or by 0.5 mg/kg BTMPS. Rats were allowed to undergo withdrawal for 48 hours after the last injection. At that time each subject was evaluated in the forced swim test. This consisted of a cylindrical tank filled to 30 cm with room water. Each rat was placed in the water for 15 min of forced swimming during a pre-test session. 72 hr after cocaine discontinuation, rats were evaluated for 5 min of forced swimming. The onset to immobility (floating) and the time spent in escape behavior (swimming or attempting to climb the wall) was measured. Cocaine withdrawal was associated with a significant decrease in the onset to immobility relative to the saline-saline and the BTMPS-cocaine groups. Cocaine withdrawal also was associated with a significant decrease in the duration of escape behavior relative to the saline-saline (P<0.047) and the BTMPS-cocaine groups. Thus BTMPS treatment during cocaine administration inhibited the expression of subsequent withdrawal behavior." @default.
- W152104336 created "2016-06-24" @default.
- W152104336 creator A5005111714 @default.
- W152104336 date "2007-01-01" @default.
- W152104336 modified "2023-09-26" @default.
- W152104336 title "Effect of the use‐dependent nicotinic receptor antagonist BTMPS on cocaine withdrawal" @default.
- W152104336 doi "https://doi.org/10.1096/fasebj.21.6.a778-d" @default.
- W152104336 hasPublicationYear "2007" @default.
- W152104336 type Work @default.
- W152104336 sameAs 152104336 @default.
- W152104336 citedByCount "0" @default.
- W152104336 crossrefType "journal-article" @default.
- W152104336 hasAuthorship W152104336A5005111714 @default.
- W152104336 hasConcept C126322002 @default.
- W152104336 hasConcept C170493617 @default.
- W152104336 hasConcept C2776885963 @default.
- W152104336 hasConcept C2777397205 @default.
- W152104336 hasConcept C2778715236 @default.
- W152104336 hasConcept C42219234 @default.
- W152104336 hasConcept C71924100 @default.
- W152104336 hasConceptScore W152104336C126322002 @default.
- W152104336 hasConceptScore W152104336C170493617 @default.
- W152104336 hasConceptScore W152104336C2776885963 @default.
- W152104336 hasConceptScore W152104336C2777397205 @default.
- W152104336 hasConceptScore W152104336C2778715236 @default.
- W152104336 hasConceptScore W152104336C42219234 @default.
- W152104336 hasConceptScore W152104336C71924100 @default.
- W152104336 hasIssue "6" @default.
- W152104336 hasLocation W1521043361 @default.
- W152104336 hasOpenAccess W152104336 @default.
- W152104336 hasPrimaryLocation W1521043361 @default.
- W152104336 hasRelatedWork W1965393569 @default.
- W152104336 hasRelatedWork W1993587201 @default.
- W152104336 hasRelatedWork W2028728636 @default.
- W152104336 hasRelatedWork W2059151436 @default.
- W152104336 hasRelatedWork W2466043692 @default.
- W152104336 hasRelatedWork W2549135832 @default.
- W152104336 hasRelatedWork W2595635579 @default.
- W152104336 hasRelatedWork W2766844642 @default.
- W152104336 hasRelatedWork W2899396768 @default.
- W152104336 hasRelatedWork W3038666778 @default.
- W152104336 hasVolume "21" @default.
- W152104336 isParatext "false" @default.
- W152104336 isRetracted "false" @default.
- W152104336 magId "152104336" @default.
- W152104336 workType "article" @default.