FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1521092162> ?p ?o ?g. }

• W1521092162 endingPage "992" @default.
• W1521092162 startingPage "984" @default.
• W1521092162 abstract "Costimulation blockade with the B7-CD28 pathway-specific agent belatacept is now used in clinical kidney transplantation, but its efficacy remains imperfect. Numerous alternate costimulatory pathways have been proposed as targets to synergize with belatacept, one of which being the inducible costimulator (ICOS)-ICOS ligand (ICOS-L) pathway. Combined ICOS-ICOS-L and CD28-B7 blockade has been shown to prevent rejection in mice, but has not been studied in primates. We therefore tested a novel ICOS-Ig human Fc-fusion protein in a nonhuman primate (NHP) kidney transplant model alone and in combination with belatacept. ICOS-Ig did not prolong rejection-free survival as a monotherapy or in combination with belatacept. In ICOS-Ig alone treated animals, most graft-infiltrating CD4(+) and CD8(+) T cells expressed ICOS, and ICOS(+) T cells were present in peripheral blood to a lesser degree. Adding belatacept reduced the proportion of graft-infiltrating ICOS(+) T cells and virtually eliminated their presence in peripheral blood. Graft-infiltrating T cells in belatacept-resistant rejection were primarily CD8(+) CD28(-) , but importantly, very few CD8(+) CD28(-) T cells expressed ICOS. We conclude that ICOS-Ig, alone or combined with belatacept, does not prolong renal allograft survival in NHPs. This may relate to selective loss of ICOS with CD28 loss." @default.
• W1521092162 created "2016-06-24" @default.
• W1521092162 creator A5000672802 @default.
• W1521092162 creator A5003099842 @default.
• W1521092162 creator A5004074203 @default.
• W1521092162 creator A5007149390 @default.
• W1521092162 creator A5008229503 @default.
• W1521092162 creator A5038249332 @default.
• W1521092162 creator A5038628496 @default.
• W1521092162 creator A5046944474 @default.
• W1521092162 creator A5056389032 @default.
• W1521092162 creator A5073283527 @default.
• W1521092162 date "2015-02-20" @default.
• W1521092162 modified "2023-10-16" @default.
• W1521092162 title "A Pilot Trial Targeting the ICOS-ICOS-L Pathway in Nonhuman Primate Kidney Transplantation" @default.
• W1521092162 cites W1484378734 @default.
• W1521092162 cites W1487911472 @default.
• W1521092162 cites W1513619062 @default.
• W1521092162 cites W1542262758 @default.
• W1521092162 cites W1547507373 @default.
• W1521092162 cites W1548331405 @default.
• W1521092162 cites W1590601327 @default.
• W1521092162 cites W1604334489 @default.
• W1521092162 cites W1626388077 @default.
• W1521092162 cites W1661441964 @default.
• W1521092162 cites W1667545291 @default.
• W1521092162 cites W1810044600 @default.
• W1521092162 cites W1922868692 @default.
• W1521092162 cites W1972388670 @default.
• W1521092162 cites W1972640898 @default.
• W1521092162 cites W1972952658 @default.
• W1521092162 cites W1976465544 @default.
• W1521092162 cites W1990429835 @default.
• W1521092162 cites W1994478925 @default.
• W1521092162 cites W1995791071 @default.
• W1521092162 cites W2013319629 @default.
• W1521092162 cites W2023037704 @default.
• W1521092162 cites W2026893575 @default.
• W1521092162 cites W2047894050 @default.
• W1521092162 cites W2052077392 @default.
• W1521092162 cites W2062146128 @default.
• W1521092162 cites W2077684987 @default.
• W1521092162 cites W2105204567 @default.
• W1521092162 cites W2114738239 @default.
• W1521092162 cites W2118061894 @default.
• W1521092162 cites W2121587664 @default.
• W1521092162 cites W2133866843 @default.
• W1521092162 cites W2143676542 @default.
• W1521092162 cites W2155335576 @default.
• W1521092162 cites W2167385707 @default.
• W1521092162 cites W4250851417 @default.
• W1521092162 doi "https://doi.org/10.1111/ajt.13100" @default.
• W1521092162 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4628789" @default.
• W1521092162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25703015" @default.
• W1521092162 hasPublicationYear "2015" @default.
• W1521092162 type Work @default.
• W1521092162 sameAs 1521092162 @default.
• W1521092162 citedByCount "30" @default.
• W1521092162 countsByYear W15210921622015 @default.
• W1521092162 countsByYear W15210921622016 @default.
• W1521092162 countsByYear W15210921622017 @default.
• W1521092162 countsByYear W15210921622018 @default.
• W1521092162 countsByYear W15210921622019 @default.
• W1521092162 countsByYear W15210921622020 @default.
• W1521092162 countsByYear W15210921622021 @default.
• W1521092162 countsByYear W15210921622022 @default.
• W1521092162 countsByYear W15210921622023 @default.
• W1521092162 crossrefType "journal-article" @default.
• W1521092162 hasAuthorship W1521092162A5000672802 @default.
• W1521092162 hasAuthorship W1521092162A5003099842 @default.
• W1521092162 hasAuthorship W1521092162A5004074203 @default.
• W1521092162 hasAuthorship W1521092162A5007149390 @default.
• W1521092162 hasAuthorship W1521092162A5008229503 @default.
• W1521092162 hasAuthorship W1521092162A5038249332 @default.
• W1521092162 hasAuthorship W1521092162A5038628496 @default.
• W1521092162 hasAuthorship W1521092162A5046944474 @default.
• W1521092162 hasAuthorship W1521092162A5056389032 @default.
• W1521092162 hasAuthorship W1521092162A5073283527 @default.
• W1521092162 hasBestOaLocation W15210921621 @default.
• W1521092162 hasConcept C126322002 @default.
• W1521092162 hasConcept C148125776 @default.
• W1521092162 hasConcept C167672396 @default.
• W1521092162 hasConcept C170493617 @default.
• W1521092162 hasConcept C203014093 @default.
• W1521092162 hasConcept C2776090121 @default.
• W1521092162 hasConcept C2778468042 @default.
• W1521092162 hasConcept C2780303639 @default.
• W1521092162 hasConcept C2780743877 @default.
• W1521092162 hasConcept C2911091166 @default.
• W1521092162 hasConcept C2994498544 @default.
• W1521092162 hasConcept C502942594 @default.
• W1521092162 hasConcept C71924100 @default.
• W1521092162 hasConcept C8891405 @default.
• W1521092162 hasConceptScore W1521092162C126322002 @default.
• W1521092162 hasConceptScore W1521092162C148125776 @default.
• W1521092162 hasConceptScore W1521092162C167672396 @default.
• W1521092162 hasConceptScore W1521092162C170493617 @default.
• W1521092162 hasConceptScore W1521092162C203014093 @default.

• next