Matches in SemOpenAlex for { <https://semopenalex.org/work/W1521132574> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1521132574 endingPage "4" @default.
- W1521132574 startingPage "21" @default.
- W1521132574 abstract "Two diol-epoxide metabolites of benzo[c]phenanthrene and benzo[a]pyrene, polynuclear aromatic hydrocarbons which occur in the environment, were tested for carcinogenicity by direct injection into the mammary fat pads of female CD rats. The compounds anti-3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene (BcPDE), a fjord region diol-epoxide, and anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, a bay region diol-epoxide, were applied at total doses of 12.2 mumol. 6-Nitrochrysene was applied at the same dose as a positive control (K. El-Bayoumy, A. Rivenson, P. Upadhyaya, Y-H. Chae, and S. S. Hecht, Cancer Res. 53: 3719-3722, 1993). The sterically hindered fjord region diol-epoxide BcPDE was a powerful mammary tumorigen and carcinogen, rapidly inducing significantly more fibroadenoma and adenocarcinoma than either of the other compounds. Anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene was a weaker mammary tumorigen than BcPDE and 6-nitrochrysene. The results of this study provide the first evidence for mammary tumorigenicity of polynuclear aromatic hydrocarbon diol-epoxides and demonstrate the potent mammary carcinogenicity of BcPDE." @default.
- W1521132574 created "2016-06-24" @default.
- W1521132574 creator A5033402104 @default.
- W1521132574 creator A5048058203 @default.
- W1521132574 creator A5069343616 @default.
- W1521132574 creator A5080527856 @default.
- W1521132574 date "1994-01-01" @default.
- W1521132574 modified "2023-10-03" @default.
- W1521132574 title "Potent mammary carcinogenicity in female CD rats of a fjord region diol-epoxide of benzo[c]phenanthrene compared to a bay region diol-epoxide of benzo[a]pyrene." @default.
- W1521132574 cites W1495618944 @default.
- W1521132574 cites W1542868541 @default.
- W1521132574 cites W1653672494 @default.
- W1521132574 cites W1817562987 @default.
- W1521132574 cites W1865108599 @default.
- W1521132574 cites W1900394297 @default.
- W1521132574 cites W2005083487 @default.
- W1521132574 cites W2006802772 @default.
- W1521132574 cites W2009972378 @default.
- W1521132574 cites W2033393251 @default.
- W1521132574 cites W2046283121 @default.
- W1521132574 cites W2048558589 @default.
- W1521132574 cites W2054114446 @default.
- W1521132574 cites W2057355166 @default.
- W1521132574 cites W2087321195 @default.
- W1521132574 cites W2090114024 @default.
- W1521132574 cites W2095619460 @default.
- W1521132574 cites W2115285962 @default.
- W1521132574 cites W2125249058 @default.
- W1521132574 cites W2128516757 @default.
- W1521132574 cites W2140131706 @default.
- W1521132574 cites W2154135601 @default.
- W1521132574 cites W223326267 @default.
- W1521132574 cites W3005477962 @default.
- W1521132574 cites W1836514107 @default.
- W1521132574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8261440" @default.
- W1521132574 hasPublicationYear "1994" @default.
- W1521132574 type Work @default.
- W1521132574 sameAs 1521132574 @default.
- W1521132574 citedByCount "15" @default.
- W1521132574 crossrefType "journal-article" @default.
- W1521132574 hasAuthorship W1521132574A5033402104 @default.
- W1521132574 hasAuthorship W1521132574A5048058203 @default.
- W1521132574 hasAuthorship W1521132574A5069343616 @default.
- W1521132574 hasAuthorship W1521132574A5080527856 @default.
- W1521132574 hasConcept C114246631 @default.
- W1521132574 hasConcept C161790260 @default.
- W1521132574 hasConcept C178790620 @default.
- W1521132574 hasConcept C185592680 @default.
- W1521132574 hasConcept C2776891815 @default.
- W1521132574 hasConcept C2776920199 @default.
- W1521132574 hasConcept C2777538855 @default.
- W1521132574 hasConcept C2778951431 @default.
- W1521132574 hasConcept C2779515768 @default.
- W1521132574 hasConcept C55493867 @default.
- W1521132574 hasConcept C71240020 @default.
- W1521132574 hasConceptScore W1521132574C114246631 @default.
- W1521132574 hasConceptScore W1521132574C161790260 @default.
- W1521132574 hasConceptScore W1521132574C178790620 @default.
- W1521132574 hasConceptScore W1521132574C185592680 @default.
- W1521132574 hasConceptScore W1521132574C2776891815 @default.
- W1521132574 hasConceptScore W1521132574C2776920199 @default.
- W1521132574 hasConceptScore W1521132574C2777538855 @default.
- W1521132574 hasConceptScore W1521132574C2778951431 @default.
- W1521132574 hasConceptScore W1521132574C2779515768 @default.
- W1521132574 hasConceptScore W1521132574C55493867 @default.
- W1521132574 hasConceptScore W1521132574C71240020 @default.
- W1521132574 hasIssue "1" @default.
- W1521132574 hasLocation W15211325741 @default.
- W1521132574 hasOpenAccess W1521132574 @default.
- W1521132574 hasPrimaryLocation W15211325741 @default.
- W1521132574 hasRelatedWork W1521132574 @default.
- W1521132574 hasRelatedWork W1526327087 @default.
- W1521132574 hasRelatedWork W1974610463 @default.
- W1521132574 hasRelatedWork W1994824322 @default.
- W1521132574 hasRelatedWork W2000618108 @default.
- W1521132574 hasRelatedWork W2089706668 @default.
- W1521132574 hasRelatedWork W2123948027 @default.
- W1521132574 hasRelatedWork W2142590214 @default.
- W1521132574 hasRelatedWork W2184728709 @default.
- W1521132574 hasRelatedWork W2323822483 @default.
- W1521132574 hasVolume "54" @default.
- W1521132574 isParatext "false" @default.
- W1521132574 isRetracted "false" @default.
- W1521132574 magId "1521132574" @default.
- W1521132574 workType "article" @default.