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- W1521142904 endingPage "101" @default.
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- W1521142904 abstract "The sections in this article are: 1 The Common Precursor to Corticotropin β-Endorphin, Melanotropins 1.1 A Short History of the Discovery of Corticotropin and Proopiomelanocortin 1.2 The Structure of the Proopiomelanocortin Precursor Molecule 1.3 Steps in Biosynthesis and Processing of Proopiomelanocortin in Anterior Pituitary 1.4 Additional Biosynthetic Steps in the Intermediate Pituitary 1.5 Proopiomelanocortin biosynthesis in Central Nervous System Neurons 1.6 Developmental Changes in the Pattern of Expression of Proopiomelanocortin 1.7 Tools to Study Proopiomelanocortin Biosynthesis 1.7.1 Primary Cultures 1.7.2 Tumor Cell Lines 2 Enzymes Responsible for Proopiomelanocortin Biosynthetic Processing 2.1 Endoproteases 2.1.1 Early Studies Involving Enzyme Isolation 2.1.2 Recent Studies Based on Molecular Approaches 2.1.3 Aspartyl and Cysteinyl Proteases 2.2 Carboxypeptidases 2.2.1 Carboxypeptidase E 2.2.2 Other Carboxypeptidases 2.3 Peptidylglycine α-amidating monooxygenase (PAM) 2.4 Cytochrome b561 2.5 α-N-acetyltransferase 2.6 Phosphorylation of Serine Residues 2.7 Glycosylation of Asparagine and Threonine 2.8 Cell Biological Aspects of Proopiomelanocortin Biosynthesis 3 Regulation of Proopiomelanocortin Synthesis, Processing, and Secretion 3.1 Responses to Environmental Stimuli 3.1.1 Copper and Ascorbate Deprivation 3.2 Responses to Hormones and Pharmacological Agents 3.2.1 Glucocorticoids 3.2.2 Dopaminergic Agents 3.2.3 Hypothalamic Stimulation 3.2.4 Thyroid Hormones 3.2.5 Sex Steroids 3.2.6 Changes with Age 4 conclusion4 Conclusion" @default.
- W1521142904 created "2016-06-24" @default.
- W1521142904 creator A5011997610 @default.
- W1521142904 creator A5015706491 @default.
- W1521142904 date "2001-12-01" @default.
- W1521142904 modified "2023-10-15" @default.
- W1521142904 title "Proopiomelanocortin Synthesis and Cell‐Specific Processing" @default.
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