Matches in SemOpenAlex for { <https://semopenalex.org/work/W1521160839> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W1521160839 abstract "In order to assess the respective contribution of the exocrine and endocrine moieties of the pancreas to the overall net uptake of selected monosaccharides by the pancreatic gland, the apparent distribution space of L-[1-14C]glucose, 3-O-[14C-methyl]-D-glucose, D-[U-14C]glucose, D-[U-14C]mannose and D-[U-14C]fructose was measured in pieces of pancreas obtained from either control rats or animals injected with streptozotocin. Although the time course for the uptake of 3-O-[14C-methyl]-D-glucose, D-[U-14C]glucose, D-[U-14C]mannose and D-[U-14C]fructose was much slower in the pieces of pancreas than that previously documented in isolated pancreatic islets, no significant difference could, as a rule, be detected between the results obtained in pancreatic pieces of control and streptozotocin rats. A comparable situation prevailed in the pancreas of animals examined 3 min after the intravenous injection of 3-O-[14C-methyl]-D-glucose. D-Glucose inhibited the uptake of 3-O-[14C-methyl]-D-glucose and that of D-[U-14C]fructose. Likewise, 3-O-methyl-D-glucose inhibited the uptake of D-[U-14C]glucose. Cytochalasin B (20 microm) also inhibited the uptake of 3-O-[14C-methyl]-D-glucose and D-[U-14C]glucose, but not that of D-[U-14C]fructose. D-Mannoheptulose hexaacetate, but not the unesterified heptose, inhibited the metabolism of tritiated and 14C-labelled D-glucose, as well as the net uptake of D-[U-14C]glucose and D-[U-14C]mannose and, to a lesser extent, that of D-[U-14C]fructose. These findings indicate that despite marked differences between endocrine and exocrine pancreatic cells in terms of both the time course for the uptake of several hexoses and the inhibition of their phosphorylation by D-mannoheptulose, little or no preferential labelling of the endocrine moiety of the pancreas by the 14C-labelled hexoses is observed, at least when judged from their distribution space in pancreatic pieces or the whole pancreatic gland. Nevertheless, the findings made with D-mannoheptulose and its hexaacetate ester raise the view that this heptose could conceivably be used to achieve a sizeable preferential labelling of the endocrine pancreas under the present experimental conditions." @default.
- W1521160839 created "2016-06-24" @default.
- W1521160839 creator A5011423271 @default.
- W1521160839 creator A5020829082 @default.
- W1521160839 creator A5040067633 @default.
- W1521160839 creator A5079092222 @default.
- W1521160839 date "2000-12-01" @default.
- W1521160839 modified "2023-10-11" @default.
- W1521160839 title "Pancreatic fate of14C-labelled hexoses" @default.
- W1521160839 doi "https://doi.org/10.1002/1099-0844(200012)18:4<281::aid-cbf884>3.0.co;2-#" @default.
- W1521160839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11180291" @default.
- W1521160839 hasPublicationYear "2000" @default.
- W1521160839 type Work @default.
- W1521160839 sameAs 1521160839 @default.
- W1521160839 citedByCount "0" @default.
- W1521160839 crossrefType "journal-article" @default.
- W1521160839 hasAuthorship W1521160839A5011423271 @default.
- W1521160839 hasAuthorship W1521160839A5020829082 @default.
- W1521160839 hasAuthorship W1521160839A5040067633 @default.
- W1521160839 hasAuthorship W1521160839A5079092222 @default.
- W1521160839 hasConcept C118859902 @default.
- W1521160839 hasConcept C126322002 @default.
- W1521160839 hasConcept C134018914 @default.
- W1521160839 hasConcept C17093226 @default.
- W1521160839 hasConcept C181199279 @default.
- W1521160839 hasConcept C185592680 @default.
- W1521160839 hasConcept C2775887612 @default.
- W1521160839 hasConcept C2776393687 @default.
- W1521160839 hasConcept C2776970464 @default.
- W1521160839 hasConcept C2778445172 @default.
- W1521160839 hasConcept C2778764654 @default.
- W1521160839 hasConcept C2779698884 @default.
- W1521160839 hasConcept C55493867 @default.
- W1521160839 hasConcept C62231903 @default.
- W1521160839 hasConcept C71924100 @default.
- W1521160839 hasConcept C86803240 @default.
- W1521160839 hasConceptScore W1521160839C118859902 @default.
- W1521160839 hasConceptScore W1521160839C126322002 @default.
- W1521160839 hasConceptScore W1521160839C134018914 @default.
- W1521160839 hasConceptScore W1521160839C17093226 @default.
- W1521160839 hasConceptScore W1521160839C181199279 @default.
- W1521160839 hasConceptScore W1521160839C185592680 @default.
- W1521160839 hasConceptScore W1521160839C2775887612 @default.
- W1521160839 hasConceptScore W1521160839C2776393687 @default.
- W1521160839 hasConceptScore W1521160839C2776970464 @default.
- W1521160839 hasConceptScore W1521160839C2778445172 @default.
- W1521160839 hasConceptScore W1521160839C2778764654 @default.
- W1521160839 hasConceptScore W1521160839C2779698884 @default.
- W1521160839 hasConceptScore W1521160839C55493867 @default.
- W1521160839 hasConceptScore W1521160839C62231903 @default.
- W1521160839 hasConceptScore W1521160839C71924100 @default.
- W1521160839 hasConceptScore W1521160839C86803240 @default.
- W1521160839 hasLocation W15211608391 @default.
- W1521160839 hasOpenAccess W1521160839 @default.
- W1521160839 hasPrimaryLocation W15211608391 @default.
- W1521160839 hasRelatedWork W120855398 @default.
- W1521160839 hasRelatedWork W1488587009 @default.
- W1521160839 hasRelatedWork W1565445921 @default.
- W1521160839 hasRelatedWork W1566961213 @default.
- W1521160839 hasRelatedWork W1603710983 @default.
- W1521160839 hasRelatedWork W1824387349 @default.
- W1521160839 hasRelatedWork W1964682123 @default.
- W1521160839 hasRelatedWork W1967168277 @default.
- W1521160839 hasRelatedWork W1969878284 @default.
- W1521160839 hasRelatedWork W1978656021 @default.
- W1521160839 hasRelatedWork W1993948072 @default.
- W1521160839 hasRelatedWork W2006910535 @default.
- W1521160839 hasRelatedWork W2041994555 @default.
- W1521160839 hasRelatedWork W2082716212 @default.
- W1521160839 hasRelatedWork W2094571862 @default.
- W1521160839 hasRelatedWork W2122923950 @default.
- W1521160839 hasRelatedWork W2178522935 @default.
- W1521160839 hasRelatedWork W2794226933 @default.
- W1521160839 hasRelatedWork W3166200582 @default.
- W1521160839 hasRelatedWork W62875106 @default.
- W1521160839 isParatext "false" @default.
- W1521160839 isRetracted "false" @default.
- W1521160839 magId "1521160839" @default.
- W1521160839 workType "article" @default.