Matches in SemOpenAlex for { <https://semopenalex.org/work/W1521171745> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W1521171745 abstract "Peroxiredoxin 6 (Prdx6) is known to play a critical role in antioxidant defense of lung and other organs. Our aim in this research was to investigate whether this protective function of Prdx6 includes an ability to repair peroxidized cell membranes. Mouse pulmonary microvascular endothelial cells (PMVECs) were treated with tert-butyl hydroperoxide (tBOOH) and lipid peroxidation was evaluated by measurement of thiobarbituric acid reactive substances (TBARS). PMVECs from Pxdx6 null mice showed much higher levels of lipid peroxidation upon tBOOH (50-300 μM) exposure compared with wild-type (WT).To determine whether Prdx6 is necessary for repair, PMVECs were treated with tBOOH (300 μM) for 24 h and then evaluated at 0,2,4 and 6 h after removal of the oxidant. TBARS in WT PMVECs returned to the levels of unexposed control level in 2 h. On the contrary, TBARS in PMVECs from Pxdx6 null mice were unchanged from their elevated levels during 6 h observation after cessation of tBOOH exposure. These results indicate that Prdx6 plays a critical role in protecting PMVECs against peroxidative stress both by preventing lipid peroxidation during the oxidant exposure and through its ability to repair peroxidized cell membrane during the subsequent recovery period following removal of the oxidative stress. Grant Funding Source: Supported by 5T32HL007748-20, RO1-HL 102011, and PO1-HL19737" @default.
- W1521171745 created "2016-06-24" @default.
- W1521171745 creator A5022854559 @default.
- W1521171745 creator A5054698138 @default.
- W1521171745 creator A5085032833 @default.
- W1521171745 date "2014-04-01" @default.
- W1521171745 modified "2023-09-26" @default.
- W1521171745 title "The protective role of peroxidase 6 against peroxidative stress in pulmonary microvascular endothelial cells includes its ability to repair peroxidized cell membranes (693.4)" @default.
- W1521171745 doi "https://doi.org/10.1096/fasebj.28.1_supplement.693.4" @default.
- W1521171745 hasPublicationYear "2014" @default.
- W1521171745 type Work @default.
- W1521171745 sameAs 1521171745 @default.
- W1521171745 citedByCount "0" @default.
- W1521171745 crossrefType "journal-article" @default.
- W1521171745 hasAuthorship W1521171745A5022854559 @default.
- W1521171745 hasAuthorship W1521171745A5054698138 @default.
- W1521171745 hasAuthorship W1521171745A5085032833 @default.
- W1521171745 hasConcept C126322002 @default.
- W1521171745 hasConcept C1491633281 @default.
- W1521171745 hasConcept C16685009 @default.
- W1521171745 hasConcept C185592680 @default.
- W1521171745 hasConcept C203014093 @default.
- W1521171745 hasConcept C2776151105 @default.
- W1521171745 hasConcept C2777352226 @default.
- W1521171745 hasConcept C2777504301 @default.
- W1521171745 hasConcept C2780829032 @default.
- W1521171745 hasConcept C55493867 @default.
- W1521171745 hasConcept C71924100 @default.
- W1521171745 hasConceptScore W1521171745C126322002 @default.
- W1521171745 hasConceptScore W1521171745C1491633281 @default.
- W1521171745 hasConceptScore W1521171745C16685009 @default.
- W1521171745 hasConceptScore W1521171745C185592680 @default.
- W1521171745 hasConceptScore W1521171745C203014093 @default.
- W1521171745 hasConceptScore W1521171745C2776151105 @default.
- W1521171745 hasConceptScore W1521171745C2777352226 @default.
- W1521171745 hasConceptScore W1521171745C2777504301 @default.
- W1521171745 hasConceptScore W1521171745C2780829032 @default.
- W1521171745 hasConceptScore W1521171745C55493867 @default.
- W1521171745 hasConceptScore W1521171745C71924100 @default.
- W1521171745 hasIssue "S1" @default.
- W1521171745 hasLocation W15211717451 @default.
- W1521171745 hasOpenAccess W1521171745 @default.
- W1521171745 hasPrimaryLocation W15211717451 @default.
- W1521171745 hasRelatedWork W1566607623 @default.
- W1521171745 hasRelatedWork W2027795887 @default.
- W1521171745 hasRelatedWork W2113027094 @default.
- W1521171745 hasRelatedWork W2280429232 @default.
- W1521171745 hasRelatedWork W2538132594 @default.
- W1521171745 hasRelatedWork W2794110069 @default.
- W1521171745 hasRelatedWork W3131757854 @default.
- W1521171745 hasRelatedWork W3157529216 @default.
- W1521171745 hasRelatedWork W4232334029 @default.
- W1521171745 hasRelatedWork W2549187990 @default.
- W1521171745 hasVolume "28" @default.
- W1521171745 isParatext "false" @default.
- W1521171745 isRetracted "false" @default.
- W1521171745 magId "1521171745" @default.
- W1521171745 workType "article" @default.