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• W1521268454 endingPage "595" @default.
• W1521268454 startingPage "588" @default.
• W1521268454 abstract "The essential cellular functions of secretion and protein degradation require a molecular machine to unfold and translocate proteins either across a membrane or into a proteolytic complex. Protein translocation is also critical for microbial pathogenesis, namely bacteria can use translocase channels to deliver toxic proteins into a target cell. Anthrax toxin (Atx), a key virulence factor secreted by Bacillus anthracis, provides a robust biophysical model to characterize transmembrane protein translocation. Atx is comprised of three proteins: the translocase component, protective antigen (PA) and two enzyme components, lethal factor (LF) and oedema factor (OF). Atx forms an active holotoxin complex containing a ring-shaped PA oligomer bound to multiple copies of LF and OF. These complexes are endocytosed into mammalian host cells, where PA forms a protein-conducting translocase channel. The proton motive force unfolds and translocates LF and OF through the channel. Recent structure and function studies have shown that LF unfolds during translocation in a force-dependent manner via a series of metastable intermediates. Polypeptide-binding clamps located throughout the PA channel catalyse substrate unfolding and translocation by stabilizing unfolding intermediates through the formation of a series of interactions with various chemical groups and α-helical structure presented by the unfolding polypeptide during translocation." @default.
• W1521268454 created "2016-06-24" @default.
• W1521268454 creator A5056599790 @default.
• W1521268454 creator A5074049305 @default.
• W1521268454 date "2011-03-28" @default.
• W1521268454 modified "2023-10-06" @default.
• W1521268454 title "The unfolding story of anthrax toxin translocation" @default.
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• W1521268454 doi "https://doi.org/10.1111/j.1365-2958.2011.07614.x" @default.
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• W1521268454 hasPublicationYear "2011" @default.
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