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• W1521369939 endingPage "562" @default.
• W1521369939 startingPage "547" @default.
• W1521369939 abstract "The airway mucosal surfaces are constantly exposed to inhaled particles that can be potentially toxic, infectious or allergenic and should elicit inflammatory changes. The proximal and distal air spaces, however, are normally infection and inflammation free due to a specialized interplay between cellular and molecular components of the pulmonary innate immune system. Surfactant protein D (SP-D) is an epithelial-cell-derived immune modulator that belongs to the small family of structurally related Ca(2+)-dependent C-type collagen-like lectins. While collectins can be detected in mucosal surfaces of various organs, SP-A and SP-D (the 'lung collectins') are constitutively expressed in the lung at high concentrations. Both proteins are considered important players of the pulmonary immune responses. Under normal conditions however, SP-A-/- mice display no pathological features in the lung. SP-D-/- mice, on the other hand, show chronic inflammatory alterations indicating a special importance of this molecule in regulating immune homeostasis and the function of the innate immune cells. Recent studies in our laboratory and others implied significant associations between changes in SP-D levels and the presence of airway inflammation both in animal models and patients raising a potential usefulness of this molecule as a disease biomarker. Research on wild-type and mutant recombinant molecules in vivo and in vitro showed that SP-D binds carbohydrates, lipids and nucleic acids with a broad spectrum specificity and initiates phagocytosis of inhaled pathogens as well as apoptotic cells. Investigations on gene-deficient and conditional over expressor mice in addition, provided evidence that SP-D directly modulates macrophage and dendritic cell function as well as T cell-dependent inflammatory events. Thus, SP-D has a unique, dual functional capacity to induce pathogen elimination on the one hand and control of pro-inflammatory mechanisms on the other, suggesting a potential suitability for therapeutic prevention and treatment of chronic airway inflammation without compromising the host defence function of the airways. This paper will review recent findings on the mechanisms of immune-protective function of SP-D in the lung." @default.
• W1521369939 created "2016-06-24" @default.
• W1521369939 creator A5013427760 @default.
• W1521369939 creator A5019375210 @default.
• W1521369939 date "2010-03-11" @default.
• W1521369939 modified "2023-09-24" @default.
• W1521369939 title "SP-D and regulation of the pulmonary innate immune system in allergic airway changes" @default.
• W1521369939 cites W1491449178 @default.
• W1521369939 cites W1544053969 @default.
• W1521369939 cites W1545754268 @default.
• W1521369939 cites W1553440365 @default.
• W1521369939 cites W1559835857 @default.
• W1521369939 cites W1571368673 @default.
• W1521369939 cites W1573118011 @default.
• W1521369939 cites W1578182072 @default.
• W1521369939 cites W1586315850 @default.
• W1521369939 cites W1588736007 @default.
• W1521369939 cites W1595806145 @default.
• W1521369939 cites W1617119238 @default.
• W1521369939 cites W1718245819 @default.
• W1521369939 cites W1752557806 @default.
• W1521369939 cites W1850437268 @default.
• W1521369939 cites W1911773168 @default.
• W1521369939 cites W192731551 @default.
• W1521369939 cites W1929253879 @default.
• W1521369939 cites W1929879919 @default.
• W1521369939 cites W1964199322 @default.
• W1521369939 cites W1966580785 @default.
• W1521369939 cites W1967939714 @default.
• W1521369939 cites W1969650622 @default.
• W1521369939 cites W1969885216 @default.
• W1521369939 cites W1969921713 @default.
• W1521369939 cites W1972561513 @default.
• W1521369939 cites W1974138511 @default.
• W1521369939 cites W1974364771 @default.
• W1521369939 cites W1974626176 @default.
• W1521369939 cites W1976432311 @default.
• W1521369939 cites W1982235565 @default.
• W1521369939 cites W1982425943 @default.
• W1521369939 cites W1984469505 @default.
• W1521369939 cites W1986450914 @default.
• W1521369939 cites W1991798034 @default.
• W1521369939 cites W1994261057 @default.
• W1521369939 cites W1995446557 @default.
• W1521369939 cites W1996736315 @default.
• W1521369939 cites W1997751057 @default.
• W1521369939 cites W1998937234 @default.
• W1521369939 cites W2001994838 @default.
• W1521369939 cites W2003566453 @default.
• W1521369939 cites W2008158905 @default.
• W1521369939 cites W2008308371 @default.
• W1521369939 cites W2011267273 @default.
• W1521369939 cites W2012782349 @default.
• W1521369939 cites W2014253214 @default.
• W1521369939 cites W2014348847 @default.
• W1521369939 cites W2018404794 @default.
• W1521369939 cites W2020012047 @default.
• W1521369939 cites W2020025471 @default.
• W1521369939 cites W2020213576 @default.
• W1521369939 cites W2021239826 @default.
• W1521369939 cites W2021644500 @default.
• W1521369939 cites W2021990733 @default.
• W1521369939 cites W2026809196 @default.
• W1521369939 cites W2028286814 @default.
• W1521369939 cites W2033450022 @default.
• W1521369939 cites W2034073109 @default.
• W1521369939 cites W2035000110 @default.
• W1521369939 cites W2037765046 @default.
• W1521369939 cites W2038801195 @default.
• W1521369939 cites W2039111226 @default.
• W1521369939 cites W2039734247 @default.
• W1521369939 cites W2044279773 @default.
• W1521369939 cites W2046073281 @default.
• W1521369939 cites W2049655268 @default.
• W1521369939 cites W2049852043 @default.
• W1521369939 cites W2049985120 @default.
• W1521369939 cites W2054076321 @default.
• W1521369939 cites W2058102221 @default.
• W1521369939 cites W2058643851 @default.
• W1521369939 cites W2063557216 @default.
• W1521369939 cites W2064121457 @default.
• W1521369939 cites W2064754019 @default.
• W1521369939 cites W2065692354 @default.
• W1521369939 cites W2065771383 @default.
• W1521369939 cites W2066124404 @default.
• W1521369939 cites W2066361433 @default.
• W1521369939 cites W2067080331 @default.
• W1521369939 cites W2069663425 @default.
• W1521369939 cites W2070364452 @default.
• W1521369939 cites W2070670097 @default.
• W1521369939 cites W2071429319 @default.
• W1521369939 cites W2072398160 @default.
• W1521369939 cites W2072569706 @default.
• W1521369939 cites W2073993023 @default.
• W1521369939 cites W2074919825 @default.
• W1521369939 cites W2075155691 @default.
• W1521369939 cites W2075214301 @default.
• W1521369939 cites W2075345380 @default.

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