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- W1521420004 abstract "This chapter discusses the identification of fibronectin as a receptor for bacterial cytoadherence. Studies on the associations between bacterial pathogens and certain host proteins likely resulted from serendipitous observations. Such was the case involving fibronectin and Staphylococcus aureus. The same could be said of perhaps many other examples of bacterial pathogens and fibronectin associations, and whether or not a bacterial pathogen bound a particular host protein was the result of a rather random screening of a library of commercially available proteins. The consequences to the host of being infected by organisms interacting with host serum proteins in general and extracellular matrix (ECM) proteins in particular are numerous, apart from the obvious feature of host parasitism through enhanced cytoadherence. For example, masking of the microbial surface might interfere with antigen presentation or prevent recognition of the foreign organism or antigens leading to an overall immune evasion strategy by the pathogen. Host proteins might impair further the more specialized functions of immune cells whose job is ligand recognition for phagocytosis. Autoimmune reactions might be envisioned, possibly the result of an altered conformation of the host protein and elicitation of autoreactive antibody, and contribute to disease pathogenesis." @default.
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- W1521420004 date "1994-01-01" @default.
- W1521420004 modified "2023-09-25" @default.
- W1521420004 title "Identification of fibronectin as a receptor for bacterial cytoadherence" @default.
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- W1521420004 doi "https://doi.org/10.1016/0076-6879(94)36024-3" @default.
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