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- W1521446670 abstract "5-Hydroxytryptamine (5-HT) receptors induce vasocontraction and play significant roles in vascular systems. We have previously shown that transactivation of EGFR contributes to α1-adrenergic receptor mediated vasocontraction. Here, we examined EGFR transactivation in 5-HT induced vascular contraction and extracellular-regulated kinase (ERK1/2) activation. Aortic contraction and intracellular [Ca2+] response to 5-HT in aorta and A7R5 cells, respectively, were obtained in the absence and presence of EGFR inhibitor (AG1478). To characterize EGFR transactivation, 5-HT stimulated-EGFR phosphorylation was determined in the absence and presence of AG1478, Ca2+/Calmodulin inhibitor (W7), Src kinase inhibitor (PP2). AG1478 attenuated 5-HT induced vasocontraction and intracellular [Ca2+] response. 5-HT mediated EGFR-transactivation was inhibited by AG1478, W7 and PP2. 5-HT also led to phosphorylation of myosin light chain kinase (MLCK) and ERK1/2 which were partially inhibited by AG1478, but completely by W7 and PP2. These data suggest that 5-HT mediated EGFR-transactivation depends on Ca2+/Calmodulin and Src-kinase and is partially involved in both vascular contractility and ERK1/2 phosphorylation in rat aorta. Grant Funding Source: This study is supported by TUBITAK 111S131" @default.
- W1521446670 created "2016-06-24" @default.
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- W1521446670 date "2014-04-01" @default.
- W1521446670 modified "2023-09-23" @default.
- W1521446670 title "5‐Hydroxytryptamine mediated vasocontraction and Ca2+/Calmodulin and Src‐kinase dependent Epidermal Growth Factor Receptor Transactivation in Rat aorta (1065.7)" @default.
- W1521446670 doi "https://doi.org/10.1096/fasebj.28.1_supplement.1065.7" @default.
- W1521446670 hasPublicationYear "2014" @default.
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