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- W1521495979 abstract "Background: Malnutrition and lean tissue wasting are common in patients with tuberculosis (TB) disease, yet little information is available on habitual dietary intake or links with body composition. Methods: Dietary intake was obtained in a randomized clinical trial of high-dose vitamin D (Vit D) in patients with pulmonary TB in Tbilisi, Georgia. Food intake was obtained (0, 8 and 16 weeks) using a validated, culture-specific tool. Serial body composition was by BMI and bioelectrical impedance analysis (BIA; % fat mass and % fat-free mass). Descriptive statistics and repeated measures ANOVA were used. Results: 192 subjects (mean age 35 y; 100 Vit D, 99 placebo) were studied. Mean daily intake of kcal, fat and protein were adequate at diagnosis and increased (with BMI) over time (time effect p<0.0001, treatment effect NS). There were no differences in % of fat mass or % fat-free mass between groups over time. Multi-drug resistant TB patients (n=23) had lower body weight, BMI (p=0.05) and fat-free mass vs. drug-susceptible patients, despite increased intake of kcal, protein, fat and CHO at 8 and 16 weeks. Conclusions: Macronutrient intake was adequate in this TB patient cohort. Increased macronutrient intake occurred concomitant with increased BMI and maintained proportions of body fat and fat-free mass. MDR-TB patients demonstrated less efficient anabolism than drug-susceptible TB patients. 1 Grant Funding Source: Supported by grants from the National Institutes of Health Fogarty grant D43 TW007124 and K24 RR0233" @default.
- W1521495979 created "2016-06-24" @default.
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- W1521495979 date "2014-04-01" @default.
- W1521495979 modified "2023-10-16" @default.
- W1521495979 title "Drug susceptibility influences macronutrient intake and body composition in tuberculosis patients (1014.4)" @default.
- W1521495979 doi "https://doi.org/10.1096/fasebj.28.1_supplement.1014.4" @default.
- W1521495979 hasPublicationYear "2014" @default.
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