FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1521509742> ?p ?o ?g. }

• W1521509742 endingPage "235" @default.
• W1521509742 startingPage "223" @default.
• W1521509742 abstract "Fab fragments of monoclonal antibodies (MoAb) to melanoma, radiolabeled with 131I, were evaluated as diagnostic reagents to determine their ability to localize systemic--MoAb injected intravenously (IV)--or nodal metastatic disease--injected subcutaneously (SQ) at a site proximal to draining lymph nodes. Sixty-one scans were performed (40 IV, 21 SQ) in 59 patients who had injections of 0.2-50 mg of 131I coupled (0.2-12 mCi) antibody. These included 48.7, which identifies a high molecular weight antigen (HMW), or 96.5, which identifies a transferrin like molecule, p97. 125I coupled nonspecific Fab 1.4, reacting with murine leukemia virus, or the whole antibody BL3, reactive with a human B cell idiotypic determinant, was generally used in tandem with the patients injected SQ as a nonspecific control. All patients had immunohistochemical studies performed on biopsied lesions and demonstrated binding to the antibodies injected. Of the IV patients, 22/38 (58%) had (+) scans, 13 at SQ or nodal sites, four at visceral sites, and five at visceral and SQ sites. Patients with clinical stage II disease had SQ injection of MoAb, including 11 additional patients injected with the whole antibody 9.2.27 (anti-HMW) labeled with 111In (6 patients) or 131I (5 patients). Nodal dissection was performed 2-4 days later. All 111In coupled antibodies demonstrated excellent nodal delineation without specific identification of tumor deposits. Of the 21 patients injected SQ with MoAb, 17 had confirmed tumor in nodes. Of patients injected with Fab fragments, 4/8 (50%) had specific uptake of MoAb, although only two were successfully imaged. Increased uptake of antimelanoma antibodies was observed in some patients in lymph nodes not containing tumor and was possibly related to antigen shedding. Clearance of labeled antibody from the injection site occurred with a half life of 16-50 hours. Toxicity was limited to local discomfort at the site of SQ injection. Melanoma metastases can be identified with IV or SQ injection or radiolabeled antibodies. These reagents may be useful in the diagnosis or therapy of human melanoma. Further evaluation will be required before they could be considered clinically useful." @default.
• W1521509742 created "2016-06-24" @default.
• W1521509742 creator A5010958930 @default.
• W1521509742 creator A5012906626 @default.
• W1521509742 creator A5024528047 @default.
• W1521509742 creator A5030761554 @default.
• W1521509742 creator A5031777285 @default.
• W1521509742 creator A5041473528 @default.
• W1521509742 creator A5042379432 @default.
• W1521509742 creator A5052780898 @default.
• W1521509742 creator A5059714974 @default.
• W1521509742 creator A5082465033 @default.
• W1521509742 date "1986-09-01" @default.
• W1521509742 modified "2023-09-23" @default.
• W1521509742 title "Monoclonal Antibody Imaging of Human Melanoma" @default.
• W1521509742 cites W1516357163 @default.
• W1521509742 cites W1521983457 @default.
• W1521509742 cites W1588459810 @default.
• W1521509742 cites W1625419967 @default.
• W1521509742 cites W1845412085 @default.
• W1521509742 cites W1885075954 @default.
• W1521509742 cites W1927649943 @default.
• W1521509742 cites W1964453753 @default.
• W1521509742 cites W1978473225 @default.
• W1521509742 cites W1979772679 @default.
• W1521509742 cites W1980545305 @default.
• W1521509742 cites W1984145337 @default.
• W1521509742 cites W1985981664 @default.
• W1521509742 cites W1991915340 @default.
• W1521509742 cites W2016292927 @default.
• W1521509742 cites W2019726352 @default.
• W1521509742 cites W2026993269 @default.
• W1521509742 cites W2030522563 @default.
• W1521509742 cites W2043635082 @default.
• W1521509742 cites W2054788533 @default.
• W1521509742 cites W2072268804 @default.
• W1521509742 cites W2081059129 @default.
• W1521509742 cites W2144907725 @default.
• W1521509742 cites W2150535269 @default.
• W1521509742 cites W2153173962 @default.
• W1521509742 cites W2270916717 @default.
• W1521509742 cites W2321067584 @default.
• W1521509742 cites W2406707654 @default.
• W1521509742 cites W2408696993 @default.
• W1521509742 cites W2410423823 @default.
• W1521509742 doi "https://doi.org/10.1097/00000658-198609000-00002" @default.
• W1521509742 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1251268" @default.
• W1521509742 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3753057" @default.
• W1521509742 hasPublicationYear "1986" @default.
• W1521509742 type Work @default.
• W1521509742 sameAs 1521509742 @default.
• W1521509742 citedByCount "46" @default.
• W1521509742 countsByYear W15215097422017 @default.
• W1521509742 countsByYear W15215097422018 @default.
• W1521509742 crossrefType "journal-article" @default.
• W1521509742 hasAuthorship W1521509742A5010958930 @default.
• W1521509742 hasAuthorship W1521509742A5012906626 @default.
• W1521509742 hasAuthorship W1521509742A5024528047 @default.
• W1521509742 hasAuthorship W1521509742A5030761554 @default.
• W1521509742 hasAuthorship W1521509742A5031777285 @default.
• W1521509742 hasAuthorship W1521509742A5041473528 @default.
• W1521509742 hasAuthorship W1521509742A5042379432 @default.
• W1521509742 hasAuthorship W1521509742A5052780898 @default.
• W1521509742 hasAuthorship W1521509742A5059714974 @default.
• W1521509742 hasAuthorship W1521509742A5082465033 @default.
• W1521509742 hasBestOaLocation W15215097422 @default.
• W1521509742 hasConcept C142724271 @default.
• W1521509742 hasConcept C147483822 @default.
• W1521509742 hasConcept C159654299 @default.
• W1521509742 hasConcept C203014093 @default.
• W1521509742 hasConcept C204232928 @default.
• W1521509742 hasConcept C2777658100 @default.
• W1521509742 hasConcept C2779720271 @default.
• W1521509742 hasConcept C2780849966 @default.
• W1521509742 hasConcept C502942594 @default.
• W1521509742 hasConcept C542903549 @default.
• W1521509742 hasConcept C71924100 @default.
• W1521509742 hasConceptScore W1521509742C142724271 @default.
• W1521509742 hasConceptScore W1521509742C147483822 @default.
• W1521509742 hasConceptScore W1521509742C159654299 @default.
• W1521509742 hasConceptScore W1521509742C203014093 @default.
• W1521509742 hasConceptScore W1521509742C204232928 @default.
• W1521509742 hasConceptScore W1521509742C2777658100 @default.
• W1521509742 hasConceptScore W1521509742C2779720271 @default.
• W1521509742 hasConceptScore W1521509742C2780849966 @default.
• W1521509742 hasConceptScore W1521509742C502942594 @default.
• W1521509742 hasConceptScore W1521509742C542903549 @default.
• W1521509742 hasConceptScore W1521509742C71924100 @default.
• W1521509742 hasIssue "3" @default.
• W1521509742 hasLocation W15215097421 @default.
• W1521509742 hasLocation W15215097422 @default.
• W1521509742 hasLocation W15215097423 @default.
• W1521509742 hasOpenAccess W1521509742 @default.
• W1521509742 hasPrimaryLocation W15215097421 @default.
• W1521509742 hasRelatedWork W2038126255 @default.
• W1521509742 hasRelatedWork W2038791604 @default.
• W1521509742 hasRelatedWork W2064089409 @default.
• W1521509742 hasRelatedWork W2073282260 @default.

• next