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- W1521543722 abstract "This chapter reviews the quantitative theories of the origin of neoplasms and discusses a new theory. It examines the theories both qualitatively and quantitatively by comparing their predictions with epidemiological and experimental observations. The theories relate the frequency and time of occurrence of tumors to the temporal and spatial distribution of oncogenic exposure. These theories are formulated for two main reasons—namely, (1) to provide a framework for evaluating the consequences of proposed mechanisms of carcinogenesis and (2) to help determine the allowable concentrations of known carcinogens in the environment and estimate the consequences of exceeding them. It is observed that some theories are needed to extrapolate the dose response relationships downward from the high doses used in animal experiments to the low doses to be allowed in the environment. To extract additional information from the statistics, which include description of the probabilities of transformation and tumor appearance provided by these theories, it is necessary to consider two kinds of variation. These variations include: (1) results from the stochastic processes within each individual and (2) the variation from one individual to another because of differences in susceptibility." @default.
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- W1521543722 date "1978-01-01" @default.
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- W1521543722 title "Quantitative Theories of Oncogenesis" @default.
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- W1521543722 doi "https://doi.org/10.1016/s0065-230x(08)60930-6" @default.
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