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- W1521567317 startingPage "329" @default.
- W1521567317 abstract "Abstract Recognized as the most common of the neurodegenerative disorders, Alzheimer's disease (AD) affects greater than 18 million people worldwide and is predicted to become the largest socioeconomic burden of the twenty‐first century. The underlying mechanism of Alzheimer's disease is as yet unknown, but the growing body of pathophysiologic evidence is beginning to point to two main causes, the formation of β‐amyloid plaques and neurofibrillary tangles. This review will cover approaches to disease modification that are based on the amyloid hypothesis; that being, the prevention of the accumulation, aggregation, and deposition of β‐amyloid peptide (Aβ) monomers, leading first to multiple oligomeric species and then to fibrils and ultimately senile plaques, is the center of focus for an approach to disease modification. There is a wealth of evidence to implicate this peptide and its subsequent aggregation in the etiology of the disease and approaches, both small molecule and biopharmaceutical, to prevent its accumulation have been the subject of much research. The vast majority of this research over the last decade has been, and continues to be, focused on these disease‐modifying, antiamyloidogenic approaches to AD. It is this subject, and the various approaches, past and present to amelioration of AD through the various agents being explored, that will be the focus of this chapter." @default.
- W1521567317 created "2016-06-24" @default.
- W1521567317 creator A5025036504 @default.
- W1521567317 creator A5062005518 @default.
- W1521567317 creator A5066195227 @default.
- W1521567317 date "2010-09-15" @default.
- W1521567317 modified "2023-10-04" @default.
- W1521567317 title "Approaches to Amyloid Therapies for the Treatment of Alzheimer's Disease" @default.
- W1521567317 cites W139300322 @default.
- W1521567317 cites W1447623510 @default.
- W1521567317 cites W1487727801 @default.
- W1521567317 cites W1494074009 @default.
- W1521567317 cites W1498127026 @default.
- W1521567317 cites W1504320357 @default.
- W1521567317 cites W1528113046 @default.
- W1521567317 cites W1535800460 @default.
- W1521567317 cites W1547035993 @default.
- W1521567317 cites W1567490604 @default.
- W1521567317 cites W1574477440 @default.
- W1521567317 cites W1584834830 @default.
- W1521567317 cites W1606372460 @default.
- W1521567317 cites W1621971853 @default.
- W1521567317 cites W1627986553 @default.
- W1521567317 cites W1644122431 @default.
- W1521567317 cites W1653912017 @default.
- W1521567317 cites W1667130205 @default.
- W1521567317 cites W1693283493 @default.
- W1521567317 cites W1705725530 @default.
- W1521567317 cites W170914365 @default.
- W1521567317 cites W1754645121 @default.
- W1521567317 cites W1797343225 @default.
- W1521567317 cites W1817515827 @default.
- W1521567317 cites W1854324009 @default.
- W1521567317 cites W1861730929 @default.
- W1521567317 cites W188237391 @default.
- W1521567317 cites W1886575365 @default.
- W1521567317 cites W1963787144 @default.
- W1521567317 cites W1965050626 @default.
- W1521567317 cites W1965214584 @default.
- W1521567317 cites W1965275873 @default.
- W1521567317 cites W1967086954 @default.
- W1521567317 cites W1967464880 @default.
- W1521567317 cites W1967549235 @default.
- W1521567317 cites W1967777458 @default.
- W1521567317 cites W1968110806 @default.
- W1521567317 cites W1968605696 @default.
- W1521567317 cites W1969262978 @default.
- W1521567317 cites W1969570944 @default.
- W1521567317 cites W1972374980 @default.
- W1521567317 cites W1972850054 @default.
- W1521567317 cites W1973600862 @default.
- W1521567317 cites W1973830433 @default.
- W1521567317 cites W1973844162 @default.
- W1521567317 cites W1974963512 @default.
- W1521567317 cites W1975448620 @default.
- W1521567317 cites W1977688919 @default.
- W1521567317 cites W1978470121 @default.
- W1521567317 cites W1978509538 @default.
- W1521567317 cites W1978736525 @default.
- W1521567317 cites W1978818669 @default.
- W1521567317 cites W1979415323 @default.
- W1521567317 cites W1979543098 @default.
- W1521567317 cites W1981654394 @default.
- W1521567317 cites W1982465696 @default.
- W1521567317 cites W1984404080 @default.
- W1521567317 cites W1984889847 @default.
- W1521567317 cites W1985623563 @default.
- W1521567317 cites W1987460136 @default.
- W1521567317 cites W1987831563 @default.
- W1521567317 cites W1988923764 @default.
- W1521567317 cites W1989206786 @default.
- W1521567317 cites W1989453114 @default.
- W1521567317 cites W1989486145 @default.
- W1521567317 cites W1989607398 @default.
- W1521567317 cites W1989654750 @default.
- W1521567317 cites W1989948422 @default.
- W1521567317 cites W1990543766 @default.
- W1521567317 cites W1991143134 @default.
- W1521567317 cites W1991989649 @default.
- W1521567317 cites W1991993391 @default.
- W1521567317 cites W1992182645 @default.
- W1521567317 cites W1993428183 @default.
- W1521567317 cites W1993469127 @default.
- W1521567317 cites W1994017422 @default.
- W1521567317 cites W1996995902 @default.
- W1521567317 cites W1997452077 @default.
- W1521567317 cites W1998227221 @default.
- W1521567317 cites W1998593025 @default.
- W1521567317 cites W1999308385 @default.
- W1521567317 cites W1999657725 @default.
- W1521567317 cites W1999660763 @default.
- W1521567317 cites W1999964462 @default.
- W1521567317 cites W2000388025 @default.
- W1521567317 cites W2000582255 @default.
- W1521567317 cites W2000917982 @default.
- W1521567317 cites W2001210466 @default.
- W1521567317 cites W2001376526 @default.
- W1521567317 cites W2001914338 @default.