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- W1521647173 abstract "Abstract Today, 20–30% of male patients with advanced germ cell tumor (GCT) do not have durable, complete remission in spite of cis-platinum (CDDP)-based chemotherapy. High-dose chemotherapy (HDCT) has been tried in CDDP refractory GCT patients. Initially HDCT was performed with autologous bone marrow transplantation in heavily treated patients. However, the clinical outcome was not good and the treatment-related death rate was not ignorable. Therefore, earlier introduction of HDCT with peripheral blood stem cell transplantation was preferable as it renders HDCT more effective and less toxic, and multicycle HDCT is feasible. The durable free rate of recent HDCT for refractory GCT patients is 32–65%. HDCT is also performed as first line chemotherapy for poor prognosis GCT patients. Induction chemotherapy followed by multicycles of HDCT was tried. The durable free rate of recent HDCT as first line chemotherapy is 43–73%. Although previous reports suggest the superiority of HDCT, one recent randomized controlled trial (RCT) failed to show an improvement with one cycle of HDCT followed by three cycles of standard-dose chemotherapy (SDCT) compared with four cycles of SDCT. Ongoing RCT comparing multicycles of HDCT with SDCT for poor prognostic GCT patients will clarify the role of HDCT. Recently, new regimens of HDCT containing paclitaxel have been devised. In this review, the history, current status and future of HDCT for advanced or refractory GCT will be discussed." @default.
- W1521647173 created "2016-06-24" @default.
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- W1521647173 date "2006-07-26" @default.
- W1521647173 modified "2023-10-14" @default.
- W1521647173 title "High-dose chemotherapy for male germ cell tumor" @default.
- W1521647173 cites W1601337213 @default.
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- W1521647173 cites W1819940966 @default.
- W1521647173 cites W1829527967 @default.
- W1521647173 cites W1868039889 @default.
- W1521647173 cites W1881843864 @default.
- W1521647173 cites W1901841823 @default.
- W1521647173 cites W1909039587 @default.
- W1521647173 cites W1916857694 @default.
- W1521647173 cites W1934533231 @default.
- W1521647173 cites W1934898490 @default.
- W1521647173 cites W1939466340 @default.
- W1521647173 cites W1956474138 @default.
- W1521647173 cites W1959252905 @default.
- W1521647173 cites W1970870660 @default.
- W1521647173 cites W1972564774 @default.
- W1521647173 cites W1973702706 @default.
- W1521647173 cites W1984784493 @default.
- W1521647173 cites W1987061854 @default.
- W1521647173 cites W1987222012 @default.
- W1521647173 cites W1990022167 @default.
- W1521647173 cites W1992984652 @default.
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- W1521647173 cites W2002737467 @default.
- W1521647173 cites W2006420519 @default.
- W1521647173 cites W2013687446 @default.
- W1521647173 cites W2030908723 @default.
- W1521647173 cites W2041636294 @default.
- W1521647173 cites W2051219283 @default.
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- W1521647173 cites W2084237567 @default.
- W1521647173 cites W2089346683 @default.
- W1521647173 cites W2099070927 @default.
- W1521647173 cites W2101281476 @default.
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- W1521647173 cites W2128723228 @default.
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- W1521647173 cites W2158532310 @default.
- W1521647173 cites W2163445411 @default.
- W1521647173 cites W2172820356 @default.
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- W1521647173 cites W2323139555 @default.
- W1521647173 cites W2412829251 @default.
- W1521647173 cites W2417618534 @default.
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- W1521647173 doi "https://doi.org/10.1111/j.1442-2042.2006.01475.x" @default.
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