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- W1521736247 abstract "Five compounds related to Congo Red were found to inhibit generation of protease-resistant prion protein in a cell-free system. In this assay Trypan Blue, Evans Blue, Sirius Red F3B, Primuline and Thioflavin-S were all more inhibitory than Congo Red itself. In scrapie-infected mouse neuroblastoma cells one compound, Sirius Red F3B, was capable of blocking the formation of protease-resistant prion protein to a similar extent as Congo Red; however, the other four compounds were less effective. Some of these compounds should be considered for testing in TSE disease models in live animals." @default.
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- W1521736247 date "2000-01-01" @default.
- W1521736247 modified "2023-09-25" @default.
- W1521736247 title "Inhibition of formation of protease-resistant prion protein by Trypan Blue, Sirius Red and other Congo Red analogs" @default.
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- W1521736247 doi "https://doi.org/10.1007/978-3-7091-6308-5_26" @default.
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