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- W1521908548 abstract "Based o computer-aided prediction of biological activity spectra using PASS computer program package, several antihypertensive drugs belonging to the group of ACE inhibitors have been selected for testing their nootropic activity. Experiments were conducted on mice by the test of spontaneous orientation (patrolling behavior) in the cross-maze. It was found that perindopril in a dose of 1 mg/kg, as well as quinapril and monopril in a dose of 10 mg/kg, improved the patrolling behavior in the cross-maze test. This effect is similar to the effects of standard nootropic drugs piracetam and meclofenoxate (in doses of 300 and 120 mg/kg, respectively). The observed nootropic effect of some ACE inhibitors are likely to be unrelated to their antihypertensive effect, since the nootropic action took place only at relatively low doses of perindopril, quinapril and monopril and was not observed with further increase in the dose. The identification of the nootropic action of antihypertensive drugs that are commonly used in clinical practice leads to their new clinical applications with allowance for the relevant individual features of patients." @default.
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- W1521908548 date "2011-04-04" @default.
- W1521908548 modified "2023-09-25" @default.
- W1521908548 title "Ноотропное действие некоторых антигипертензивных препаратов: компьютерный прогноз и экспериментальное тестирование" @default.
- W1521908548 doi "https://doi.org/10.30906/0023-1134-2011-45-10-25-31" @default.
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