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- W1521963497 abstract "Simple point mutations can confer profound phenotypes on pathogens and parasites of major public health importance, such as malaria. In particular, single nucleotide polymporphisms (SNPs) are known to easily arise, where one base changes occur in the parasite genomic sequence. These SNPs may confer resistance to malaria therapeutic or preventive drugs, or even render other as yet uncharacterized phenotypes of public health concern, such as virulence. Modern advances in parasite molecular biology and genomics allow the typing of parasites with a range of levels of detail. Particular SNPs or combinations of these are identified which are associated with resistance, followed by confirmation through genetic cross experiments. Using simple polymerase chain reaction (PCR) techniques, the point mutations are now increasingly applied as molecular markers for tracking and containment of resistant malaria. These marker point mutations are particularly instrumental surveillance tools as they enable efficient detection of drugresistant parasites or pathogens before escalation to a public health toll." @default.
- W1521963497 created "2016-06-24" @default.
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- W1521963497 date "2012-03-21" @default.
- W1521963497 modified "2023-10-18" @default.
- W1521963497 title "Point Mutation in Surveillance of Drug-Resistant Malaria" @default.
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- W1521963497 doi "https://doi.org/10.5772/35185" @default.
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