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• W1521965743 startingPage "1859" @default.
• W1521965743 abstract "1-β-d-Arabinofuranosylcytosine (ara-C) inhibited growth of monkey kidney, LM, LM(TK-), and HeLa cells and inhibited DNA biosynthesis in monkey kidney and LM cell cultures.The thymidine (TdR) kinase activities of green monkey kidney (GMK or CV-1) and HeLa, but not LM or LM(TK-), cell cultures were greatly increased after ara-C treatment. A smaller increase of deoxycytidylic (dCMP) deaminase, but not of the thymidylic (TMP) kinase activity, was also found. The induction of TdR kinase activity by ara-C was prevented by cycloheximide.Addition to the cultures of arabinofuranosylthymine (ara-T), arabinofuranosyluracil (ara-U), TdR, deoxyuridine (UdR), or cytidine did not produce increases in the TdR kinase activity comparable to those produced by ara-C treatment, and the addition of TdR, UdR, or cytidine to cultures treated with ara-C did not alter the ara-C-induced stimulation of TdR kinase.Ara-T, ara-U, and ara-C did not inhibit either the enzymatic phosphorylation of UdR-3H or the deamination of dCMP-3H. Deoxycytidine, when added to cultures at the same time as ara-C, prevented the increase in TdR kinase and, when added 24 hr after the ara-C treatment, reversed the ara-C induction of TdR kinase.Mitomycin C (15–25 µg/ml), another inhibitor of DNA biosynthesis, induced about a 4-fold increase in the TdR kinase activity. However, TdR kinase activity was not stimulated in cultures treated with 50 or 100 µg/ml mitomycin C." @default.
• W1521965743 created "2016-06-24" @default.
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• W1521965743 date "1966-09-01" @default.
• W1521965743 modified "2023-09-23" @default.
• W1521965743 title "Arabinofuranosylcytosine-induced stimulation of thymidine kinase and deoxycytidylic deaminase activities of mammalian cultures." @default.
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• W1521965743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4958937" @default.
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