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• W1522014793 abstract "The extracellular matrix (ECM) is important for both structural integrity and functions of the brain. Matrix metalloproteinases (MMPs) play major roles in ECM-remodeling under both physiological and pathological conditions. Reversion-inducing cysteine-rich protein with Kazal motifs (Reck) is a membrane-anchored MMP-regulator implicated in coordinated regulation of pericellular proteolysis. Although patho-physiological importance of MMPs and another group of MMP-regulators, tissue inhibitor of metalloproteinases, in brain ischemia has been demonstrated, little is known about the role of Reck in this process. In this study, we found that Reck is up-regulated in hippocampus and penumbra of subventricular zone after transient cerebral ischemia in mice. Most of the Reck-positive cells found at day 2 after ischemia are positive for Nestin as well as Ki67 and localized to the CA2 region of the hippocampus. At day 7 after ischemia, the Reck-positive cells increased in number, extended processes, expressed the reactive astrocyte marker GFAP and the neuronal marker NF200, and were widely distributed in the hippocampus. In the mutant mice carrying single functional Reck allele (Reck+/-), tissue damage and cell death after cerebral ischemia were augmented, the recovery of long-term potentiation in the hippocampus was compromised, NR2C subunit of NMDA receptor was up-regulated, gelatinolytic activity of MMPs were up-regulated and laminin-immunoreactivity was reduced. Our data implicate Reck in protection of ECM/tissue integrity and promotion of functional recovery in the brain after transient cerebral ischemia." @default.
• W1522014793 created "2016-06-24" @default.
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• W1522014793 date "2010-08-25" @default.
• W1522014793 modified "2023-10-09" @default.
• W1522014793 title "The Reck tumor suppressor protein alleviates tissue damage and promotes functional recovery after transient cerebral ischemia in mice" @default.
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• W1522014793 cites W1898323316 @default.
• W1522014793 cites W1911664005 @default.
• W1522014793 cites W1964708370 @default.
• W1522014793 cites W1969083970 @default.
• W1522014793 cites W1976143652 @default.
• W1522014793 cites W1978542087 @default.
• W1522014793 cites W1984801123 @default.
• W1522014793 cites W1993930504 @default.
• W1522014793 cites W1998005675 @default.
• W1522014793 cites W1999495459 @default.
• W1522014793 cites W2004085515 @default.
• W1522014793 cites W2007001870 @default.
• W1522014793 cites W2007639322 @default.
• W1522014793 cites W2008469777 @default.
• W1522014793 cites W2009812062 @default.
• W1522014793 cites W2010268515 @default.
• W1522014793 cites W2010735934 @default.
• W1522014793 cites W2011221727 @default.
• W1522014793 cites W2013877892 @default.
• W1522014793 cites W2014547350 @default.
• W1522014793 cites W2015612267 @default.
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• W1522014793 cites W2019111748 @default.
• W1522014793 cites W2021762355 @default.
• W1522014793 cites W2023250693 @default.
• W1522014793 cites W2036900989 @default.
• W1522014793 cites W2040400232 @default.
• W1522014793 cites W2046329404 @default.
• W1522014793 cites W2047908523 @default.
• W1522014793 cites W2049511526 @default.
• W1522014793 cites W2052358946 @default.
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• W1522014793 cites W2063175209 @default.
• W1522014793 cites W2064046485 @default.
• W1522014793 cites W2069845573 @default.
• W1522014793 cites W2079054696 @default.
• W1522014793 cites W2081923855 @default.
• W1522014793 cites W2082194278 @default.
• W1522014793 cites W2084596562 @default.
• W1522014793 cites W2086386772 @default.
• W1522014793 cites W2088209389 @default.
• W1522014793 cites W2095484045 @default.
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• W1522014793 doi "https://doi.org/10.1111/j.1471-4159.2010.06933.x" @default.
• W1522014793 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20796170" @default.
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