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- W152203264 abstract "Inflammatory bowel disease (IBD) is a group of idiopathic chronic relapsing inflammatoryconditions of the gastrointestinal tract. The precise etiology of IBD is unknown,although it is clearly multifactorial resulting from interplay of genetic, environmentaland immunological factors. Epidemiological studies show that the incidence of IBDand other autoimmune disorders is low in the developing countries and more in thedeveloped countries. Evidence suggests that therapeutic administration of helminthcan reduce the symptoms of IBD in both animal models and man. However, one studyshow the rat tapeworm Hymenolepis diminuta infection results in significant exacerbationof oxazolone induced colitis in mice (Hunter et al., 2007). The mechanisms bywhich helminths interact with the gut immune system in IBD-susceptible hosts, particularlytheir effect on the onset and progression of colitis are poorly understood. Toaddress this we have investigated the interaction between Trichuris muris and themdr1a (-/-) mouse model, which lacks the epithelial barrier protein, p-glycoprotein andslowly develops a spontaneous colitis in the presence of a normal gut flora." @default.
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- W152203264 date "2008-12-01" @default.
- W152203264 modified "2023-09-27" @default.
- W152203264 title "Inflammatory Bowel Disease and Trichuris muris" @default.
- W152203264 doi "https://doi.org/10.1097/00054725-200812003-00145" @default.
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