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• W1522145110 abstract "The main function of a ligament is to connect one bone to another bone across a joint, keeping them aligned to prevent abnormal motions and dislocations. The typical magnitude of force a ligament may experience during day-to-day activities varies. For example the anterior cruciate ligament of the knee can be exposed to daily tensile forces ranging between 67N for ascending stairs to 630N for jogging (Vunjak-Novakovic, Altman et al. 2004), whereas large loads, exceeding 1800N, can cause rupturing. Depending upon anatomical location and the extent of vascularisation, the ligament may or may not be capable of selfhealing after a rupture. Some of the most frequently ruptured ligaments occur in the knee joint, often through sporting activities such as skiing, football and basketball and the number of injuries are increasing each year (Cooper, Lu et al. 2005). Ninety percent of knee ligament injuries involve the anterior cruciate ligament (ACL) and medial collateral ligament (MCL) (Woo, Abramowitch et al. 2006). The MCL can self-heal, but the ACL cannot due to poor vascularisation. Because of this, alternative methods such as regenerative medicine have focused heavily upon the ACL with the aim of producing a fully functional tissue in vitro. Figures indicate that approximately 250,000 people are diagnosed with ACL injuries each year in the USA (Doroski and Brink 2007), and approximately 150,000 need to undergo surgical treatment, known as an ACL reconstruction (Cooper, Lu et al. 2005). If the rupture is not treated it can cause loss of function of the associated joint which can then lead to early development of osteoarthritis (Cooper and Bailey 2006; Gentleman, Livesay et al. 2006). The current gold standard procedure for an ACL reconstruction is surgical autografting. This involves using part of the patients own patellar tendon, hamstring or quadriceps to replace the ruptured ACL (Beasley, Weiland et al. 2005). However, these techniques cause donor site morbidity (Goulet and Germain 1997; Van Eijk, Saris et al. 2004; Cooper and Bailey 2006; Hairfield-Stein, England et al. 2007) which is associated with pain and a recovery period for the donor tissue site (Cooper, Lu et al. 2005; Hairfield-Stein, England et al. 2007). Generally 75-90% of patients have good or excellent long term success rates from these current grafting techniques (regarding functional stability and symptomatic relief upon return to normal activities) but unfortunately a substantial number of patients exist who have unsatisfactory results which could be attributed to graft failure (Vergis and Gillquist 1995). Some of these patients continue to endure pain, suffer from loss of motion secondary to the operative procedure and continue with recurrent instability (Vergis and Gillquist 1995), while others suffer from degenerative joint disease such as arthritis or" @default.
• W1522145110 created "2016-06-24" @default.
• W1522145110 creator A5072822168 @default.
• W1522145110 creator A5076472691 @default.
• W1522145110 date "2011-08-17" @default.
• W1522145110 modified "2023-10-16" @default.
• W1522145110 title "Tissue Engineering of Ligaments" @default.
• W1522145110 cites W149720224 @default.
• W1522145110 cites W1601068592 @default.
• W1522145110 cites W1632592232 @default.
• W1522145110 cites W1824966615 @default.
• W1522145110 cites W1966260681 @default.
• W1522145110 cites W1966952941 @default.
• W1522145110 cites W1971339046 @default.
• W1522145110 cites W1972141619 @default.
• W1522145110 cites W1974405261 @default.
• W1522145110 cites W1975926911 @default.
• W1522145110 cites W1977515801 @default.
• W1522145110 cites W1977798161 @default.
• W1522145110 cites W1982380369 @default.
• W1522145110 cites W1986399426 @default.
• W1522145110 cites W1986948053 @default.
• W1522145110 cites W1989412047 @default.
• W1522145110 cites W1990851605 @default.
• W1522145110 cites W1991096907 @default.
• W1522145110 cites W1993607801 @default.
• W1522145110 cites W1993988392 @default.
• W1522145110 cites W1995039059 @default.
• W1522145110 cites W1995203179 @default.
• W1522145110 cites W1995610687 @default.
• W1522145110 cites W2000833954 @default.
• W1522145110 cites W2001316553 @default.
• W1522145110 cites W2002627642 @default.
• W1522145110 cites W2003251092 @default.
• W1522145110 cites W2003748808 @default.
• W1522145110 cites W2006762534 @default.
• W1522145110 cites W2008029193 @default.
• W1522145110 cites W2008880236 @default.
• W1522145110 cites W2015457622 @default.
• W1522145110 cites W2016064986 @default.
• W1522145110 cites W2016726612 @default.
• W1522145110 cites W2018042656 @default.
• W1522145110 cites W2019229136 @default.
• W1522145110 cites W2020678183 @default.
• W1522145110 cites W2021159296 @default.
• W1522145110 cites W2029969442 @default.
• W1522145110 cites W2030667189 @default.
• W1522145110 cites W2032655864 @default.
• W1522145110 cites W2034091561 @default.
• W1522145110 cites W2039517105 @default.
• W1522145110 cites W2041831926 @default.
• W1522145110 cites W2045403433 @default.
• W1522145110 cites W2045466471 @default.
• W1522145110 cites W2045477439 @default.
• W1522145110 cites W2046377580 @default.
• W1522145110 cites W2047272458 @default.
• W1522145110 cites W2051123301 @default.
• W1522145110 cites W2051786101 @default.
• W1522145110 cites W2051900137 @default.
• W1522145110 cites W2053284589 @default.
• W1522145110 cites W2055037957 @default.
• W1522145110 cites W2058377142 @default.
• W1522145110 cites W2058833394 @default.
• W1522145110 cites W2059112825 @default.
• W1522145110 cites W2062376568 @default.
• W1522145110 cites W2065536055 @default.
• W1522145110 cites W2065836836 @default.
• W1522145110 cites W2066284148 @default.
• W1522145110 cites W2066714907 @default.
• W1522145110 cites W2069059879 @default.
• W1522145110 cites W2071352906 @default.
• W1522145110 cites W2077848608 @default.
• W1522145110 cites W2079280255 @default.
• W1522145110 cites W2081586208 @default.
• W1522145110 cites W2083887869 @default.
• W1522145110 cites W2084365441 @default.
• W1522145110 cites W2084610464 @default.
• W1522145110 cites W2086269269 @default.
• W1522145110 cites W2087933180 @default.
• W1522145110 cites W209422636 @default.
• W1522145110 cites W2101383386 @default.
• W1522145110 cites W2103259282 @default.
• W1522145110 cites W2108910200 @default.
• W1522145110 cites W2119830722 @default.
• W1522145110 cites W2123349384 @default.
• W1522145110 cites W2137188329 @default.
• W1522145110 cites W2139355825 @default.
• W1522145110 cites W2141425377 @default.
• W1522145110 cites W2142634963 @default.
• W1522145110 cites W2151165961 @default.
• W1522145110 cites W2154177449 @default.
• W1522145110 cites W2155423228 @default.
• W1522145110 cites W2158315808 @default.
• W1522145110 cites W2161042785 @default.
• W1522145110 cites W2166544197 @default.
• W1522145110 cites W2166912059 @default.
• W1522145110 cites W2169160123 @default.
• W1522145110 cites W2172914696 @default.
• W1522145110 cites W615823245 @default.
• W1522145110 cites W2266926202 @default.

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