FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1522157027> ?p ?o ?g. }

• W1522157027 endingPage "8" @default.
• W1522157027 startingPage "6035" @default.
• W1522157027 abstract "Insulin receptor substrate 1 (IRS-1) is a major substrate of insulin, insulin-like growth factors, and cytokine signaling and plays an important role in mediating apoptosis, cell differentiation, and cell transformation. We found that IRS-1 is constitutively activated in a variety of solid tumors, including breast cancers, leiomyomas, Wilms' tumors, rhabdomyosarcomas, liposarcomas, leiomyosarcomas, and adrenal cortical carcinomas. Blocking the constitutively activated IRS-1 signaling in breast cancer cells with a dominant-negative IRS-1, an IRS-1 with all 18 potential tyrosine-phosphorylation sites replaced by phenylalanines (F18), dramatically reduced cancer cell growth. Breast cancer cells that expressed F18 also formed smaller and far fewer colonies in soft agar culture than did the cells that did not express F18. These studies suggest that constitutive IRS-1 activation is a common phenomenon in tumors and that activated IRS-1 may present an attractive therapeutic target." @default.
• W1522157027 created "2016-06-24" @default.
• W1522157027 creator A5018073672 @default.
• W1522157027 creator A5040359760 @default.
• W1522157027 creator A5042060039 @default.
• W1522157027 creator A5054486557 @default.
• W1522157027 creator A5090872806 @default.
• W1522157027 date "2002-11-01" @default.
• W1522157027 modified "2023-09-27" @default.
• W1522157027 title "Constitutive activation of insulin receptor substrate 1 is a frequent event in human tumors: therapeutic implications." @default.
• W1522157027 cites W1501449620 @default.
• W1522157027 cites W1529014602 @default.
• W1522157027 cites W1973372369 @default.
• W1522157027 cites W1981661908 @default.
• W1522157027 cites W2005650787 @default.
• W1522157027 cites W2008532096 @default.
• W1522157027 cites W2031938665 @default.
• W1522157027 cites W2033249060 @default.
• W1522157027 cites W2051758765 @default.
• W1522157027 cites W2063361476 @default.
• W1522157027 cites W2064801081 @default.
• W1522157027 cites W2066358136 @default.
• W1522157027 cites W2068345721 @default.
• W1522157027 cites W2071049538 @default.
• W1522157027 cites W2078121507 @default.
• W1522157027 cites W2090663223 @default.
• W1522157027 cites W2092319601 @default.
• W1522157027 cites W2102033127 @default.
• W1522157027 cites W2121179344 @default.
• W1522157027 cites W2122312605 @default.
• W1522157027 cites W2123431152 @default.
• W1522157027 cites W2161810908 @default.
• W1522157027 cites W2319176918 @default.
• W1522157027 cites W2322168524 @default.
• W1522157027 cites W48874134 @default.
• W1522157027 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12414625" @default.
• W1522157027 hasPublicationYear "2002" @default.
• W1522157027 type Work @default.
• W1522157027 sameAs 1522157027 @default.
• W1522157027 citedByCount "37" @default.
• W1522157027 countsByYear W15221570272012 @default.
• W1522157027 countsByYear W15221570272013 @default.
• W1522157027 countsByYear W15221570272014 @default.
• W1522157027 countsByYear W15221570272015 @default.
• W1522157027 countsByYear W15221570272016 @default.
• W1522157027 countsByYear W15221570272017 @default.
• W1522157027 countsByYear W15221570272018 @default.
• W1522157027 countsByYear W15221570272020 @default.
• W1522157027 countsByYear W15221570272023 @default.
• W1522157027 crossrefType "journal-article" @default.
• W1522157027 hasAuthorship W1522157027A5018073672 @default.
• W1522157027 hasAuthorship W1522157027A5040359760 @default.
• W1522157027 hasAuthorship W1522157027A5042060039 @default.
• W1522157027 hasAuthorship W1522157027A5054486557 @default.
• W1522157027 hasAuthorship W1522157027A5090872806 @default.
• W1522157027 hasConcept C112446052 @default.
• W1522157027 hasConcept C121608353 @default.
• W1522157027 hasConcept C126322002 @default.
• W1522157027 hasConcept C134018914 @default.
• W1522157027 hasConcept C201624660 @default.
• W1522157027 hasConcept C2777391703 @default.
• W1522157027 hasConcept C2777553839 @default.
• W1522157027 hasConcept C2779306644 @default.
• W1522157027 hasConcept C42362537 @default.
• W1522157027 hasConcept C502942594 @default.
• W1522157027 hasConcept C62478195 @default.
• W1522157027 hasConcept C71924100 @default.
• W1522157027 hasConcept C86803240 @default.
• W1522157027 hasConcept C95444343 @default.
• W1522157027 hasConceptScore W1522157027C112446052 @default.
• W1522157027 hasConceptScore W1522157027C121608353 @default.
• W1522157027 hasConceptScore W1522157027C126322002 @default.
• W1522157027 hasConceptScore W1522157027C134018914 @default.
• W1522157027 hasConceptScore W1522157027C201624660 @default.
• W1522157027 hasConceptScore W1522157027C2777391703 @default.
• W1522157027 hasConceptScore W1522157027C2777553839 @default.
• W1522157027 hasConceptScore W1522157027C2779306644 @default.
• W1522157027 hasConceptScore W1522157027C42362537 @default.
• W1522157027 hasConceptScore W1522157027C502942594 @default.
• W1522157027 hasConceptScore W1522157027C62478195 @default.
• W1522157027 hasConceptScore W1522157027C71924100 @default.
• W1522157027 hasConceptScore W1522157027C86803240 @default.
• W1522157027 hasConceptScore W1522157027C95444343 @default.
• W1522157027 hasIssue "21" @default.
• W1522157027 hasLocation W15221570271 @default.
• W1522157027 hasOpenAccess W1522157027 @default.
• W1522157027 hasPrimaryLocation W15221570271 @default.
• W1522157027 hasRelatedWork W2022588964 @default.
• W1522157027 hasRelatedWork W2040513019 @default.
• W1522157027 hasRelatedWork W2053685370 @default.
• W1522157027 hasRelatedWork W2064754233 @default.
• W1522157027 hasRelatedWork W2077304944 @default.
• W1522157027 hasRelatedWork W2100118978 @default.
• W1522157027 hasRelatedWork W2109607186 @default.
• W1522157027 hasRelatedWork W2167633432 @default.
• W1522157027 hasRelatedWork W2167843337 @default.
• W1522157027 hasRelatedWork W2172065567 @default.
• W1522157027 hasVolume "62" @default.

• next