FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1522198934> ?p ?o ?g. }

• W1522198934 endingPage "448" @default.
• W1522198934 startingPage "437" @default.
• W1522198934 abstract "Background and Purpose Nuclear factor erythroid 2‐related factor ( N rf2) is a transcription factor that up‐regulates a diverse array of antioxidant genes and protects cells from oxidative damage. This study is designed to determine whether D ‐ L ‐ s ulforaphane ( SFN ) can protect neural crest cells ( NCCs ), an ethanol‐sensitive cell population implicated in fetal alcohol spectrum disorders, against ethanol‐induced apoptosis and whether protective effects of SFN are mediated by the induction of N rf2‐mediated antioxidant response. Experimental Approach Control, SFN ‐treated or N rf2‐ siRNA transfected NCCs were exposed to ethanol. N rf2 activation, the expression and activities of N rf2 downstream antioxidant proteins, reactive oxygen species generation and apoptosis were determined in control and ethanol‐exposed NCCs . Key Results Exposure of NCCs to SFN alone significantly increased N rf2 activation and the expression of N rf2 downstream antioxidants as well as the activities of the antioxidant enzymes. Treatment of NCCs with SFN along with ethanol significantly decreased ethanol‐induced oxidative stress and apoptosis. In contrast, knockdown of N rf2 by siRNA significantly increased the sensitivity of NCCs to ethanol‐induced oxidative stress and apoptosis. Suppression of N rf2 signalling in NCCs also significantly diminished SFN ‐mediated antioxidant response and abolished the protective effects of SFN on ethanol‐induced oxidative stress and apoptosis. Conclusions and Implications These results demonstrated that N rf2‐mediated antioxidant response plays an important role in the susceptibility of NCCs to ethanol‐induced oxidative stress and apoptosis and that the protection of SFN against ethanol‐induced oxidative stress and apoptosis in NCCs is mediated by the induction of N rf2 signalling." @default.
• W1522198934 created "2016-06-24" @default.
• W1522198934 creator A5013012960 @default.
• W1522198934 creator A5035282947 @default.
• W1522198934 creator A5052870947 @default.
• W1522198934 date "2013-04-25" @default.
• W1522198934 modified "2023-10-18" @default.
• W1522198934 title "Sulforaphane protects against ethanol-induced oxidative stress and apoptosis in neural crest cells by the induction of Nrf2-mediated antioxidant response" @default.
• W1522198934 cites W1601723864 @default.
• W1522198934 cites W1856997783 @default.
• W1522198934 cites W1984254481 @default.
• W1522198934 cites W1986099314 @default.
• W1522198934 cites W1991222695 @default.
• W1522198934 cites W1991530716 @default.
• W1522198934 cites W1996630410 @default.
• W1522198934 cites W1999274929 @default.
• W1522198934 cites W1999925834 @default.
• W1522198934 cites W2000310038 @default.
• W1522198934 cites W2001072821 @default.
• W1522198934 cites W2001486727 @default.
• W1522198934 cites W2007143913 @default.
• W1522198934 cites W2008901235 @default.
• W1522198934 cites W2015392958 @default.
• W1522198934 cites W2021270662 @default.
• W1522198934 cites W2031403700 @default.
• W1522198934 cites W2031849170 @default.
• W1522198934 cites W2036328573 @default.
• W1522198934 cites W2037839678 @default.
• W1522198934 cites W2038950626 @default.
• W1522198934 cites W2044412157 @default.
• W1522198934 cites W2050714633 @default.
• W1522198934 cites W2056778388 @default.
• W1522198934 cites W2057855533 @default.
• W1522198934 cites W2059586911 @default.
• W1522198934 cites W2063236277 @default.
• W1522198934 cites W2065401390 @default.
• W1522198934 cites W2073255901 @default.
• W1522198934 cites W2076966095 @default.
• W1522198934 cites W2081432821 @default.
• W1522198934 cites W2083387782 @default.
• W1522198934 cites W2088649765 @default.
• W1522198934 cites W2092603433 @default.
• W1522198934 cites W2095447228 @default.
• W1522198934 cites W2096000363 @default.
• W1522198934 cites W2097634036 @default.
• W1522198934 cites W2105455720 @default.
• W1522198934 cites W2113521816 @default.
• W1522198934 cites W2116978833 @default.
• W1522198934 cites W2124524961 @default.
• W1522198934 cites W2125899400 @default.
• W1522198934 cites W2131153615 @default.
• W1522198934 cites W2140172033 @default.
• W1522198934 cites W2141703798 @default.
• W1522198934 cites W2145212391 @default.
• W1522198934 cites W2146558971 @default.
• W1522198934 cites W2151350157 @default.
• W1522198934 cites W2154171046 @default.
• W1522198934 cites W2158022427 @default.
• W1522198934 cites W2164182667 @default.
• W1522198934 cites W2170886788 @default.
• W1522198934 cites W55749515 @default.
• W1522198934 doi "https://doi.org/10.1111/bph.12133" @default.
• W1522198934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3651668" @default.
• W1522198934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23425096" @default.
• W1522198934 hasPublicationYear "2013" @default.
• W1522198934 type Work @default.
• W1522198934 sameAs 1522198934 @default.
• W1522198934 citedByCount "67" @default.
• W1522198934 countsByYear W15221989342013 @default.
• W1522198934 countsByYear W15221989342014 @default.
• W1522198934 countsByYear W15221989342015 @default.
• W1522198934 countsByYear W15221989342016 @default.
• W1522198934 countsByYear W15221989342017 @default.
• W1522198934 countsByYear W15221989342018 @default.
• W1522198934 countsByYear W15221989342019 @default.
• W1522198934 countsByYear W15221989342020 @default.
• W1522198934 countsByYear W15221989342021 @default.
• W1522198934 countsByYear W15221989342022 @default.
• W1522198934 countsByYear W15221989342023 @default.
• W1522198934 crossrefType "journal-article" @default.
• W1522198934 hasAuthorship W1522198934A5013012960 @default.
• W1522198934 hasAuthorship W1522198934A5035282947 @default.
• W1522198934 hasAuthorship W1522198934A5052870947 @default.
• W1522198934 hasBestOaLocation W15221989342 @default.
• W1522198934 hasConcept C185592680 @default.
• W1522198934 hasConcept C190283241 @default.
• W1522198934 hasConcept C2776151105 @default.
• W1522198934 hasConcept C2778004101 @default.
• W1522198934 hasConcept C2780841255 @default.
• W1522198934 hasConcept C48349386 @default.
• W1522198934 hasConcept C55493867 @default.
• W1522198934 hasConcept C86803240 @default.
• W1522198934 hasConcept C95444343 @default.
• W1522198934 hasConceptScore W1522198934C185592680 @default.
• W1522198934 hasConceptScore W1522198934C190283241 @default.
• W1522198934 hasConceptScore W1522198934C2776151105 @default.
• W1522198934 hasConceptScore W1522198934C2778004101 @default.
• W1522198934 hasConceptScore W1522198934C2780841255 @default.

• next