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- W1522203620 abstract "Mitomycin C/sodium periodate, (IO4−)-treated lymphocytes and other cells stimulate blastogenic transformation of allogeneic lymphocytes. Peak [3H]TdR incorporation occurs at 2–3 days, as with IO4−-induced autologous mixed lymphocyte reactions, in contrast to the more delayed response that occurs in the usual allogeneic mixed lymphocyte reaction. IO4−-treated HeLa cells, three T and three B lymphoid cell lines stimulated a rapid response. Another B lymphoid cell line stimulated only a delayed response (peak at 5–6 days) whether or not the cells were exposed to IO4−. IO4−-treated platelets and other cell lines did not stimulate lymphocytes. Glass-adherent cells (GAC) were necessary for direct IO4− stimulation of lymphocytes and for IO4−-induced autologous and allogeneic mixed lymphocytes reactions (MLR), with one exception. IO4−-treated HeLa cells stimulated lymphocytes in the absence of GAC, suggesting that HeLa cells and GAC possess a common helper property." @default.
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- W1522203620 date "1977-06-01" @default.
- W1522203620 modified "2023-09-25" @default.
- W1522203620 title "Periodate-induced lymphocyte transformation" @default.
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- W1522203620 doi "https://doi.org/10.1016/0014-4827(77)90398-6" @default.
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