FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1522262736> ?p ?o ?g. }

• W1522262736 endingPage "5580" @default.
• W1522262736 startingPage "5572" @default.
• W1522262736 abstract "In the accompanying paper [Adams, H., Scotti, P.A., de Cock, H., Luirink, J. & Tommassen, J. (2002) Eur. J. Biochem.269, 5564–5571], we showed that the precursor of outer-membrane protein PhoE of Escherichia coli with a Gly to Leu substitution at position −10 in the signal sequence (G-10L) is targeted to the SecYEG translocon via the signal-recognition particle (SRP) route, instead of via the SecB pathway. Here, we studied the fate of the mutant precursor in a prlA4 mutant strain. prlA mutations, located in the secY gene, have been isolated as suppressors that restore the export of precursors with defective signal sequences. Remarkably, the G-10L mutant precursor, which is normally exported in a wild-type strain, accumulated strongly in a prlA4 mutant strain. In vitro cross-linking experiments revealed that the precursor is correctly targeted to the prlA4 mutant translocon. However, translocation across the cytoplasmic membrane was defective, as appeared from proteinase K-accessibility experiments in pulse-labeled cells. Furthermore, the mutant precursor was found to accumulate when expressed in a secY40 mutant, which is defective in the insertion of integral-membrane proteins but not in protein translocation. Together, these data suggest that SecB and SRP substrates are differently processed at the SecYEG translocon." @default.
• W1522262736 created "2016-06-24" @default.
• W1522262736 creator A5013360331 @default.
• W1522262736 creator A5054756900 @default.
• W1522262736 creator A5054822118 @default.
• W1522262736 creator A5090879577 @default.
• W1522262736 date "2002-10-30" @default.
• W1522262736 modified "2023-09-27" @default.
• W1522262736 title "Defective translocation of a signal sequence mutant in aprlA4suppressor strain ofEscherichia coli" @default.
• W1522262736 cites W106446473 @default.
• W1522262736 cites W1276010910 @default.
• W1522262736 cites W1492342681 @default.
• W1522262736 cites W1515662611 @default.
• W1522262736 cites W1554414192 @default.
• W1522262736 cites W1571527733 @default.
• W1522262736 cites W1598140832 @default.
• W1522262736 cites W1604376210 @default.
• W1522262736 cites W1607150245 @default.
• W1522262736 cites W1667874699 @default.
• W1522262736 cites W1747708829 @default.
• W1522262736 cites W1751401440 @default.
• W1522262736 cites W1848544460 @default.
• W1522262736 cites W1910636673 @default.
• W1522262736 cites W1922612002 @default.
• W1522262736 cites W1968143836 @default.
• W1522262736 cites W1992800404 @default.
• W1522262736 cites W1997391192 @default.
• W1522262736 cites W2002785901 @default.
• W1522262736 cites W2006271637 @default.
• W1522262736 cites W2009067269 @default.
• W1522262736 cites W2013131393 @default.
• W1522262736 cites W2028510180 @default.
• W1522262736 cites W2041976154 @default.
• W1522262736 cites W2042814467 @default.
• W1522262736 cites W2048737734 @default.
• W1522262736 cites W2053092155 @default.
• W1522262736 cites W2056891601 @default.
• W1522262736 cites W2069088839 @default.
• W1522262736 cites W2073075045 @default.
• W1522262736 cites W2074179726 @default.
• W1522262736 cites W2078787129 @default.
• W1522262736 cites W2082142372 @default.
• W1522262736 cites W2082307070 @default.
• W1522262736 cites W2091482732 @default.
• W1522262736 cites W2091645600 @default.
• W1522262736 cites W2094624515 @default.
• W1522262736 cites W2096190827 @default.
• W1522262736 cites W2097534440 @default.
• W1522262736 cites W2101848104 @default.
• W1522262736 cites W2109709152 @default.
• W1522262736 cites W2115474397 @default.
• W1522262736 cites W2115558294 @default.
• W1522262736 cites W2115825240 @default.
• W1522262736 cites W2119566573 @default.
• W1522262736 cites W2121689536 @default.
• W1522262736 cites W2123310015 @default.
• W1522262736 cites W2124380712 @default.
• W1522262736 cites W2124781934 @default.
• W1522262736 cites W2126106174 @default.
• W1522262736 cites W2133904476 @default.
• W1522262736 cites W2134385780 @default.
• W1522262736 cites W2146567236 @default.
• W1522262736 cites W2153134143 @default.
• W1522262736 cites W2159586138 @default.
• W1522262736 cites W2162060803 @default.
• W1522262736 cites W2166161543 @default.
• W1522262736 cites W2169220413 @default.
• W1522262736 cites W242232373 @default.
• W1522262736 cites W297443420 @default.
• W1522262736 cites W59314449 @default.
• W1522262736 doi "https://doi.org/10.1046/j.1432-1033.2002.03263.x" @default.
• W1522262736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12423356" @default.
• W1522262736 hasPublicationYear "2002" @default.
• W1522262736 type Work @default.
• W1522262736 sameAs 1522262736 @default.
• W1522262736 citedByCount "1" @default.
• W1522262736 crossrefType "journal-article" @default.
• W1522262736 hasAuthorship W1522262736A5013360331 @default.
• W1522262736 hasAuthorship W1522262736A5054756900 @default.
• W1522262736 hasAuthorship W1522262736A5054822118 @default.
• W1522262736 hasAuthorship W1522262736A5090879577 @default.
• W1522262736 hasConcept C104317684 @default.
• W1522262736 hasConcept C10858879 @default.
• W1522262736 hasConcept C138626823 @default.
• W1522262736 hasConcept C143065580 @default.
• W1522262736 hasConcept C146587185 @default.
• W1522262736 hasConcept C167625842 @default.
• W1522262736 hasConcept C186175293 @default.
• W1522262736 hasConcept C199229279 @default.
• W1522262736 hasConcept C2779190341 @default.
• W1522262736 hasConcept C501734568 @default.
• W1522262736 hasConcept C547475151 @default.
• W1522262736 hasConcept C55493867 @default.
• W1522262736 hasConcept C86803240 @default.
• W1522262736 hasConcept C95444343 @default.
• W1522262736 hasConceptScore W1522262736C104317684 @default.
• W1522262736 hasConceptScore W1522262736C10858879 @default.
• W1522262736 hasConceptScore W1522262736C138626823 @default.

• next