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- W1522276317 endingPage "13140" @default.
- W1522276317 startingPage "13106" @default.
- W1522276317 abstract "The use of protein X-ray crystallography for structure-based design of small-molecule drugs is well-documented and includes several notable success stories. However, it is less well-known that structural biology has emerged as a major tool for the design of novel vaccine antigens. Here, we review the important contributions that protein crystallography has made so far to vaccine research and development. We discuss several examples of the crystallographic characterization of vaccine antigen structures, alone or in complexes with ligands or receptors. We cover the critical role of high-resolution epitope mapping by reviewing structures of complexes between antigens and their cognate neutralizing, or protective, antibody fragments. Most importantly, we provide recent examples where structural insights obtained via protein crystallography have been used to design novel optimized vaccine antigens. This review aims to illustrate the value of protein crystallography in the emerging discipline of structural vaccinology and its impact on the rational design of vaccines." @default.
- W1522276317 created "2016-06-24" @default.
- W1522276317 creator A5008027591 @default.
- W1522276317 creator A5009243601 @default.
- W1522276317 creator A5017976977 @default.
- W1522276317 date "2015-06-09" @default.
- W1522276317 modified "2023-10-18" @default.
- W1522276317 title "Protein Crystallography in Vaccine Research and Development" @default.
- W1522276317 cites W1574987843 @default.
- W1522276317 cites W1587979196 @default.
- W1522276317 cites W1867042358 @default.
- W1522276317 cites W1915391240 @default.
- W1522276317 cites W1963829486 @default.
- W1522276317 cites W1964521329 @default.
- W1522276317 cites W1964889794 @default.
- W1522276317 cites W1965495205 @default.
- W1522276317 cites W1969156185 @default.
- W1522276317 cites W1969760654 @default.
- W1522276317 cites W1971773700 @default.
- W1522276317 cites W1975355256 @default.
- W1522276317 cites W1977315164 @default.
- W1522276317 cites W1978769714 @default.
- W1522276317 cites W1979359179 @default.
- W1522276317 cites W1979768873 @default.
- W1522276317 cites W1985854865 @default.
- W1522276317 cites W1988459634 @default.
- W1522276317 cites W1988661023 @default.
- W1522276317 cites W1989501142 @default.
- W1522276317 cites W1989544708 @default.
- W1522276317 cites W1990642036 @default.
- W1522276317 cites W1993366615 @default.
- W1522276317 cites W1993928780 @default.
- W1522276317 cites W1996112440 @default.
- W1522276317 cites W1996319727 @default.
- W1522276317 cites W1996993889 @default.
- W1522276317 cites W1999483871 @default.
- W1522276317 cites W2000885937 @default.
- W1522276317 cites W2001169808 @default.
- W1522276317 cites W2002218492 @default.
- W1522276317 cites W2003123340 @default.
- W1522276317 cites W2003464399 @default.
- W1522276317 cites W2003506374 @default.
- W1522276317 cites W2004436328 @default.
- W1522276317 cites W2005061720 @default.
- W1522276317 cites W2005967422 @default.
- W1522276317 cites W2007950357 @default.
- W1522276317 cites W2009084519 @default.
- W1522276317 cites W2011328856 @default.
- W1522276317 cites W2012660080 @default.
- W1522276317 cites W2012763858 @default.
- W1522276317 cites W2018470704 @default.
- W1522276317 cites W2019500839 @default.
- W1522276317 cites W2022391208 @default.
- W1522276317 cites W2022949657 @default.
- W1522276317 cites W2026501972 @default.
- W1522276317 cites W2026602862 @default.
- W1522276317 cites W2028478463 @default.
- W1522276317 cites W2029875065 @default.
- W1522276317 cites W2031204432 @default.
- W1522276317 cites W2032347855 @default.
- W1522276317 cites W2032796397 @default.
- W1522276317 cites W2033882116 @default.
- W1522276317 cites W2036301066 @default.
- W1522276317 cites W2036826769 @default.
- W1522276317 cites W2037320559 @default.
- W1522276317 cites W2038442395 @default.
- W1522276317 cites W2039478502 @default.
- W1522276317 cites W2040299410 @default.
- W1522276317 cites W2040417686 @default.
- W1522276317 cites W2043056303 @default.
- W1522276317 cites W2045515452 @default.
- W1522276317 cites W2046452372 @default.
- W1522276317 cites W2047705460 @default.
- W1522276317 cites W2051918553 @default.
- W1522276317 cites W2052277371 @default.
- W1522276317 cites W2052937459 @default.
- W1522276317 cites W2053240723 @default.
- W1522276317 cites W2053940732 @default.
- W1522276317 cites W2053991371 @default.
- W1522276317 cites W2054392131 @default.
- W1522276317 cites W2057519548 @default.
- W1522276317 cites W2059359501 @default.
- W1522276317 cites W2061059781 @default.
- W1522276317 cites W2063853836 @default.
- W1522276317 cites W2066344543 @default.
- W1522276317 cites W2066521937 @default.
- W1522276317 cites W2067767201 @default.
- W1522276317 cites W2070545278 @default.
- W1522276317 cites W2071513218 @default.
- W1522276317 cites W2072220396 @default.
- W1522276317 cites W2073469793 @default.
- W1522276317 cites W2074179519 @default.
- W1522276317 cites W2074294128 @default.
- W1522276317 cites W2074610853 @default.
- W1522276317 cites W2078239992 @default.
- W1522276317 cites W2081644937 @default.
- W1522276317 cites W2082104101 @default.
- W1522276317 cites W2082713375 @default.