FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1522278345> ?p ?o ?g. }

• W1522278345 endingPage "2913" @default.
• W1522278345 startingPage "2908" @default.
• W1522278345 abstract "Abstract Progress in unraveling the biology of myeloma has suffered from lack of an in vitro or in vivo system for reproducible growth of myeloma cells and development of disease manifestations. The SCID-hu mouse harbors a human microenvironment in the form of human fetal bone. Myeloma cells from the bone marrow of 80% of patients readily grew in the human environment of SCID-hu mice. Engraftment of myeloma cells was followed by detectable human Ig levels in the murine blood. Myeloma-bearing mice had high levels of monotypic human Igs, high blood calcium levels, increased osteoclast activity, and severe resorption of the human bones. The human microenvironment was infiltrated with Epstein-Barr virus-negative monoclonal myeloma cells of the same clonality as the original myeloma cells. Active angiogenesis was apparent in areas of myeloma cell infiltration; the new endothelial cells were of human origin. We conclude that the SCID-hu mouse is a favorable host for studying the biology and therapy of myeloma and that a normal bone marrow environment can support the growth of myeloma cells. © 1998 by The American Society of Hematology." @default.
• W1522278345 created "2016-06-24" @default.
• W1522278345 creator A5000879635 @default.
• W1522278345 creator A5038021934 @default.
• W1522278345 creator A5039870327 @default.
• W1522278345 date "1998-10-15" @default.
• W1522278345 modified "2023-10-02" @default.
• W1522278345 title "Primary Myeloma Cells Growing in SCID-hu Mice: A Model for Studying the Biology and Treatment of Myeloma and Its Manifestations" @default.
• W1522278345 cites W145333022 @default.
• W1522278345 cites W1554644107 @default.
• W1522278345 cites W1792320115 @default.
• W1522278345 cites W187389121 @default.
• W1522278345 cites W1983386156 @default.
• W1522278345 cites W1988605844 @default.
• W1522278345 cites W2027860241 @default.
• W1522278345 cites W2035766149 @default.
• W1522278345 cites W2067379331 @default.
• W1522278345 cites W2068705764 @default.
• W1522278345 cites W2088111660 @default.
• W1522278345 cites W2090248921 @default.
• W1522278345 cites W2097593324 @default.
• W1522278345 cites W2097710494 @default.
• W1522278345 cites W2120860584 @default.
• W1522278345 cites W2126009525 @default.
• W1522278345 cites W2154083433 @default.
• W1522278345 cites W2154819235 @default.
• W1522278345 cites W2165788078 @default.
• W1522278345 cites W2177390859 @default.
• W1522278345 cites W2249893093 @default.
• W1522278345 cites W2262776735 @default.
• W1522278345 cites W2276983539 @default.
• W1522278345 cites W2409125979 @default.
• W1522278345 cites W2474583326 @default.
• W1522278345 cites W3111493210 @default.
• W1522278345 cites W94332232 @default.
• W1522278345 doi "https://doi.org/10.1182/blood.v92.8.2908" @default.
• W1522278345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9763577" @default.
• W1522278345 hasPublicationYear "1998" @default.
• W1522278345 type Work @default.
• W1522278345 sameAs 1522278345 @default.
• W1522278345 citedByCount "252" @default.
• W1522278345 countsByYear W15222783452012 @default.
• W1522278345 countsByYear W15222783452013 @default.
• W1522278345 countsByYear W15222783452014 @default.
• W1522278345 countsByYear W15222783452015 @default.
• W1522278345 countsByYear W15222783452016 @default.
• W1522278345 countsByYear W15222783452017 @default.
• W1522278345 countsByYear W15222783452018 @default.
• W1522278345 countsByYear W15222783452019 @default.
• W1522278345 countsByYear W15222783452020 @default.
• W1522278345 countsByYear W15222783452021 @default.
• W1522278345 countsByYear W15222783452022 @default.
• W1522278345 countsByYear W15222783452023 @default.
• W1522278345 crossrefType "journal-article" @default.
• W1522278345 hasAuthorship W1522278345A5000879635 @default.
• W1522278345 hasAuthorship W1522278345A5038021934 @default.
• W1522278345 hasAuthorship W1522278345A5039870327 @default.
• W1522278345 hasConcept C142724271 @default.
• W1522278345 hasConcept C194409129 @default.
• W1522278345 hasConcept C202751555 @default.
• W1522278345 hasConcept C203014093 @default.
• W1522278345 hasConcept C2776033226 @default.
• W1522278345 hasConcept C2776364478 @default.
• W1522278345 hasConcept C2780007613 @default.
• W1522278345 hasConcept C2780394083 @default.
• W1522278345 hasConcept C502942594 @default.
• W1522278345 hasConcept C55493867 @default.
• W1522278345 hasConcept C71924100 @default.
• W1522278345 hasConcept C86803240 @default.
• W1522278345 hasConceptScore W1522278345C142724271 @default.
• W1522278345 hasConceptScore W1522278345C194409129 @default.
• W1522278345 hasConceptScore W1522278345C202751555 @default.
• W1522278345 hasConceptScore W1522278345C203014093 @default.
• W1522278345 hasConceptScore W1522278345C2776033226 @default.
• W1522278345 hasConceptScore W1522278345C2776364478 @default.
• W1522278345 hasConceptScore W1522278345C2780007613 @default.
• W1522278345 hasConceptScore W1522278345C2780394083 @default.
• W1522278345 hasConceptScore W1522278345C502942594 @default.
• W1522278345 hasConceptScore W1522278345C55493867 @default.
• W1522278345 hasConceptScore W1522278345C71924100 @default.
• W1522278345 hasConceptScore W1522278345C86803240 @default.
• W1522278345 hasIssue "8" @default.
• W1522278345 hasLocation W15222783451 @default.
• W1522278345 hasOpenAccess W1522278345 @default.
• W1522278345 hasPrimaryLocation W15222783451 @default.
• W1522278345 hasRelatedWork W2005843898 @default.
• W1522278345 hasRelatedWork W2041170438 @default.
• W1522278345 hasRelatedWork W2066639236 @default.
• W1522278345 hasRelatedWork W2067621609 @default.
• W1522278345 hasRelatedWork W2073598146 @default.
• W1522278345 hasRelatedWork W2081378286 @default.
• W1522278345 hasRelatedWork W2092430089 @default.
• W1522278345 hasRelatedWork W2408784386 @default.
• W1522278345 hasRelatedWork W2415489728 @default.
• W1522278345 hasRelatedWork W3028819550 @default.
• W1522278345 hasVolume "92" @default.
• W1522278345 isParatext "false" @default.
• W1522278345 isRetracted "false" @default.

• next