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• W1522440679 abstract "Introduction: Based on early studies of non-motor function in the cerebellum and dysfunction in the cerebellum of post-traumatic stress disorder (PTSD) patients, we presumed that the cerebellum was involved in the neuropathology of cognitive and emotional processing of PTSD patients, while the density of some sub-areas of the cerebellum of PTSD patients was most likely abnormal. Methods: Eleven female victims of rape with PTSD and 12 age-matched female normal controls received 1.5 T 3D magnetic resonance imaging (MRI) scan. The scans were then analyzed using the voxel-based morphometry 2 (VBM2) toolbox. Results: Victims of rape with PTSD showed increased cerebellum density on the left side compared with normal controls (P<0.001), especially in the pyramis (x=−9, y=−72, z=−36; k=519; t=4.70), uvula (x=−4, y=−66, z=−35; k=256; t=4.02), declive (x=−6, y=−69, z=−30; k=213; t=3.84) and nodule (x=−4, y=−63, z=−31; k=147; t=3.93). In addition, compared with normal controls, the PTSD group showed significant differences in gray matter density of other brain areas, including the frontal lobe, parietal lobe, occipital lobe (P<0.001), insula, posterior cingulate, amygdala and hippocampus (P<0.005). Discussion: These finding suggest that the cerebellum may be involved in the neuropathology and functional compensation in the neurocircuitry of PTSD." @default.
• W1522440679 created "2016-06-24" @default.
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• W1522440679 date "2010-09-30" @default.
• W1522440679 modified "2023-10-16" @default.
• W1522440679 title "Abnormal cerebellum density in victims of rape with post-traumatic stress disorder: Voxel-based analysis of magnetic resonance imaging investigation" @default.
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• W1522440679 doi "https://doi.org/10.1111/j.1758-5872.2010.00076.x" @default.
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