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- W1522472351 abstract "Introduction: The zinc-finger transcription factor Krϋppel-like factor 2 (KLF2)transduces physical forces of blood flow into molecular signals responsible for a widerange of biological responses. KLF2 maintains a healthy, quiescent endothelialphenotype. I studied the expression and function of the zebrafish KLF2 ortholog klf2a invascular biology.Materials and Methods: Expression patterns of genes were observed using Whole-mount in situ hybridisation (WISH) technique. Relative expressions of genes wereinvestigated using reverse transcription quantitative polymerase chain reaction (RT-qPCR). Particle imaging velocimetry (PIV) method was used to measure blood flowvelocities. Blood flow in zebrafish embryos was manipulated genetically andpharmacologically. Transcription Activator-Like Effector Nucleases (TALEN) were usedto generate a stable klf2a mutant line. Western blot, mass spectrometry andimmunoprecipitation techniques were used in Klf2a protein studies. klf2a mutant lineswere crossed with several transgenic reporter lines to study the role of klf2a in vasculardevelopment and transcription.Results: I reproduced and extended previous studies of spatial and temporal klf2a expression patterns. I confirmed that this expression is dependent on blood flow. Morpholino-mediated klf2a knockdown was used to study the roles of klf2a in regulation of other previously identified flow-dependent genes. klf2a mutants were generated and phenotyped. The mutant phenotype was compared to the one seen in klf2a MO morphants." @default.
- W1522472351 created "2016-06-24" @default.
- W1522472351 creator A5025245063 @default.
- W1522472351 date "2014-07-01" @default.
- W1522472351 modified "2023-09-23" @default.
- W1522472351 title "The role of the transcription factor klf2a in vascular biology" @default.
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