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- W1522473364 abstract "Abstract Regulatory CD4+FoxP3+ T cells (Treg) are key regulators of inflammation and control the magnitude of cellular immune responses to viral infections. However, little is known about Treg regulation of recall responses to previously-encountered pathogens. Here we investigated the influence of Treg on recall responses to influenza virus infection. Utilizing influenza NP311-325/I-Ab Class II tetramers, we tracked the antigen (Ag)-specific Treg during primary and secondary influenza virus infections in C57BL/6 mice. Ag-specific Treg accumulated in the lung-draining lymph node and lung parenchyma during secondary virus infection with accelerated kinetics relative to primary influenza infection, suggesting the existence of a “memory” Treg pool. These Treg contributed to the control of in vivo responses to secondary influenza infection by limiting the magnitude of the Ag-specific memory CD8+ T cell recall response and by contributing to the control of pulmonary inflammation as well as airway chemokine/cytokine expression. In vitro studies verified that memory Treg cells can effectively control the proliferation of memory CD8+ T cells in an Ag-specific fashion, and that this regulatory function was MHC class II dependent. Together, these data demonstrate a previously unappreciated role for Treg in shaping the cellular immune response to secondary influenza virus challenges and need to be considered during vaccine development." @default.
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- W1522473364 date "2012-05-01" @default.
- W1522473364 modified "2023-09-27" @default.
- W1522473364 title "Memory Treg cells regulate the immune response to influenza virus infection (170.10)" @default.
- W1522473364 doi "https://doi.org/10.4049/jimmunol.188.supp.170.10" @default.
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