FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1522526853> ?p ?o ?g. }

• W1522526853 endingPage "278" @default.
• W1522526853 startingPage "268" @default.
• W1522526853 abstract "The Pla surface protease of Yersinia pestis, encoded by the Y. pestis-specific plasmid pPCP1, is a versatile virulence factor. In vivo studies have shown that Pla is essential in the establishment of bubonic plague, and in vitro studies have demonstrated various putative virulence functions for the Pla molecule. Pla is a surface protease of the omptin family, and its proteolytic targets include the abundant, circulating human zymogen plasminogen, which is activated by Pla to the serine protease plasmin. Plasmin is important in cell migration, and Pla also proteolytically inactivates the main circulating inhibitor of plasmin, alpha2-antiplasmin. Pla also is an adhesin with affinity for laminin, a major glycoprotein of mammalian basement membranes, which is degraded by plasmin but not by Pla. Together, these functions create uncontrolled plasmin proteolysis targeted at tissue barriers. Other proteolytic targets for Pla include complement proteins. Pla also mediates bacterial invasion into human endothelial cell lines; the adhesive and invasive charateristics of Pla can be genetically dissected from its proteolytic activity. Pla is a 10-stranded antiparallel beta-barrel with five surface-exposed short loops, where the catalytic residues are oriented inwards at the top of the beta-barrel. The sequence of Pla contains a three-dimensional motif for protein binding to lipid A of the lipopolysaccharide. Indeed, the proteolytic activity of Pla requires rough lipopolysaccharide but is sterically inhibited by the O antigen in smooth LPS, which may be the selective advantage of the loss of O antigen in Y. pestis. Members of the omptin family are highly similar in structure but differ in functions and virulence association. The catalytic residues of omptins are conserved, but the variable substrate specificities in proteolysis by Pla and other omptins are dictated by the amino acid sequences near or at the surface loops, and hence reflect differences in substrate binding. The closest orthologs of Pla are PgtE of Salmonella and Epo of Erwinia, which functionally differ from Pla. Pla gives a model of how a horizontally transferred protein fold can diverge into a powerful virulence factor through adaptive mutations." @default.
• W1522526853 created "2016-06-24" @default.
• W1522526853 creator A5001072062 @default.
• W1522526853 creator A5033403912 @default.
• W1522526853 creator A5037158829 @default.
• W1522526853 creator A5038683391 @default.
• W1522526853 creator A5042074660 @default.
• W1522526853 creator A5046764458 @default.
• W1522526853 creator A5051296067 @default.
• W1522526853 creator A5052169915 @default.
• W1522526853 creator A5079366131 @default.
• W1522526853 date "2007-01-01" @default.
• W1522526853 modified "2023-10-06" @default.
• W1522526853 title "Using Every Trick in the Book: The Pla Surface Protease of Yersinia pestis" @default.
• W1522526853 cites W1494421077 @default.
• W1522526853 cites W1539032192 @default.
• W1522526853 cites W1575381144 @default.
• W1522526853 cites W1812041024 @default.
• W1522526853 cites W1958474746 @default.
• W1522526853 cites W1963536396 @default.
• W1522526853 cites W1980112487 @default.
• W1522526853 cites W2008911461 @default.
• W1522526853 cites W2014477644 @default.
• W1522526853 cites W2019402019 @default.
• W1522526853 cites W2033951844 @default.
• W1522526853 cites W2034453568 @default.
• W1522526853 cites W2039997350 @default.
• W1522526853 cites W2044270465 @default.
• W1522526853 cites W2066756817 @default.
• W1522526853 cites W2067206056 @default.
• W1522526853 cites W2072617582 @default.
• W1522526853 cites W2074178106 @default.
• W1522526853 cites W2075551281 @default.
• W1522526853 cites W2089901384 @default.
• W1522526853 cites W2096812889 @default.
• W1522526853 cites W2105591932 @default.
• W1522526853 cites W2106826257 @default.
• W1522526853 cites W2108415726 @default.
• W1522526853 cites W2112950614 @default.
• W1522526853 cites W2128931069 @default.
• W1522526853 cites W2130272389 @default.
• W1522526853 cites W2144230942 @default.
• W1522526853 cites W2145912774 @default.
• W1522526853 cites W2155828191 @default.
• W1522526853 cites W2158978517 @default.
• W1522526853 cites W2169010145 @default.
• W1522526853 cites W2172052459 @default.
• W1522526853 doi "https://doi.org/10.1007/978-0-387-72124-8_24" @default.
• W1522526853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17966423" @default.
• W1522526853 hasPublicationYear "2007" @default.
• W1522526853 type Work @default.
• W1522526853 sameAs 1522526853 @default.
• W1522526853 citedByCount "35" @default.
• W1522526853 countsByYear W15225268532012 @default.
• W1522526853 countsByYear W15225268532013 @default.
• W1522526853 countsByYear W15225268532014 @default.
• W1522526853 countsByYear W15225268532015 @default.
• W1522526853 countsByYear W15225268532016 @default.
• W1522526853 countsByYear W15225268532017 @default.
• W1522526853 countsByYear W15225268532019 @default.
• W1522526853 countsByYear W15225268532020 @default.
• W1522526853 countsByYear W15225268532021 @default.
• W1522526853 crossrefType "book-chapter" @default.
• W1522526853 hasAuthorship W1522526853A5001072062 @default.
• W1522526853 hasAuthorship W1522526853A5033403912 @default.
• W1522526853 hasAuthorship W1522526853A5037158829 @default.
• W1522526853 hasAuthorship W1522526853A5038683391 @default.
• W1522526853 hasAuthorship W1522526853A5042074660 @default.
• W1522526853 hasAuthorship W1522526853A5046764458 @default.
• W1522526853 hasAuthorship W1522526853A5051296067 @default.
• W1522526853 hasAuthorship W1522526853A5052169915 @default.
• W1522526853 hasAuthorship W1522526853A5079366131 @default.
• W1522526853 hasConcept C104317684 @default.
• W1522526853 hasConcept C153911025 @default.
• W1522526853 hasConcept C181199279 @default.
• W1522526853 hasConcept C185592680 @default.
• W1522526853 hasConcept C2776714187 @default.
• W1522526853 hasConcept C2777807008 @default.
• W1522526853 hasConcept C2778222588 @default.
• W1522526853 hasConcept C2781071845 @default.
• W1522526853 hasConcept C2781307694 @default.
• W1522526853 hasConcept C55493867 @default.
• W1522526853 hasConcept C60987743 @default.
• W1522526853 hasConcept C86803240 @default.
• W1522526853 hasConcept C89423630 @default.
• W1522526853 hasConceptScore W1522526853C104317684 @default.
• W1522526853 hasConceptScore W1522526853C153911025 @default.
• W1522526853 hasConceptScore W1522526853C181199279 @default.
• W1522526853 hasConceptScore W1522526853C185592680 @default.
• W1522526853 hasConceptScore W1522526853C2776714187 @default.
• W1522526853 hasConceptScore W1522526853C2777807008 @default.
• W1522526853 hasConceptScore W1522526853C2778222588 @default.
• W1522526853 hasConceptScore W1522526853C2781071845 @default.
• W1522526853 hasConceptScore W1522526853C2781307694 @default.
• W1522526853 hasConceptScore W1522526853C55493867 @default.
• W1522526853 hasConceptScore W1522526853C60987743 @default.
• W1522526853 hasConceptScore W1522526853C86803240 @default.
• W1522526853 hasConceptScore W1522526853C89423630 @default.

• next