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- W1522553255 abstract "1.1 Stem cell (SC) therapy is not a new concept. In the aftermath of the bombings of Hiroshima and Nagasaki in 1945, researchers discovered that bone marrow transplanted into irradiated mice produced hematopoiesis (Lorenz, 1951). Hematopoietic stem cells (HSCs) were first identified in 1961 and their ability to migrate and differentiate into multiple cell types was documented (Till, 1961). Distinct SC types have been established from embryos and identified in the fetal tissues and umbilical cord blood (UCB) as well as in specific niches in many adult mammalian tissues and organs such as bone marrow (BM), brain, skin, eyes, heart, kidneys, lungs, gastrointestinal tract, pancreas, liver, breast, ovaries, prostate and testis (Siqueira, 2010). All SCs are undifferentiated cells that exhibit unlimited self renewal and can generate multiple cell lineages or more restricted progenitor populations which can contribute to tissue homeostasis by replenishing the cells or to tissue regeneration after injury (Lanza, 2004; Mimeault, 2006). Several investigations (Mimeault, 2006; Ortiz-Gonzalez, 2004; Trounson, 2006) have been carried out with isolated embryonic, fetal and adult SCs in a well-defined culture microenvironment to define the sequential steps and intracellular pathways that are involved in their differentiation into the specific cell lineages. More particularly, different methods have been developed for the in vitro culture of SCs, including the use of cell feeder layers, cell-free conditions, extracellular matrix molecules such as collagen, gelatin and laminin and diverse growth factors and cytokines (Mimeault, 2004; Siqueira, 2010)." @default.
- W1522553255 created "2016-06-24" @default.
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- W1522553255 date "2011-10-12" @default.
- W1522553255 modified "2023-10-03" @default.
- W1522553255 title "Stem-Cell Therapy for Retinal Diseases" @default.
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- W1522553255 doi "https://doi.org/10.5772/22830" @default.
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