Matches in SemOpenAlex for { <https://semopenalex.org/work/W1522782786> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1522782786 endingPage "R177" @default.
- W1522782786 startingPage "R177" @default.
- W1522782786 abstract "Diffuse alveolar hemorrhage (DAH) is a serious pulmonary complication seen in patients with autoimmune disorders and patients treated with chemotherapy or after hematopoietic stem cell transplantation. The clinical management of DAH is complex and the condition has a high mortality rate. Tissue factor is expressed in the lung alveoli during inflammation and therefore pulmonary administration of human recombinant activated factor VIIa (rFVIIa) could be a rational treatment option.Six patients with acute, bronchoscopically confirmed DAH from a single intensive care unit university hospital center were included in the study of acute DAH in critically ill patients. The patients were treated with intrapulmonary administration of 50 microg/kg rFVIIa in 50 ml of sodium chloride by bronchoalveolar lavage (BAL) with 25 ml in each of the main bronchi, which was repeated after 24 hours in case of treatment failure.An excellent response, defined as complete and sustained hemostasis after a single dose of rFVIIa, was seen in three patients. A good response, meaning that sustained hemostasis was achieved by a repeated rFVIIa administration, was seen in the remaining three patients. In one of these patients, the BAL treatment was repeated twice; in another patient, the second dose of rFVIIa was administered by nebulizer after extubation after the initial BAL. The hemostatic effect was statistically significant (p = 0.031). The oxygenation capacity, as reflected by the PaO2/FiO2 (arterial oxygen pressure/inspiratory fractional oxygen content) ratio, increased significantly (p = 0.024) in all six patients following the local rFVIIa therapy.Symptomatic therapy of DAH after intrapulmonary administration of one or more doses of rFVIIa was found to have a good to excellent hemostatic effect in six consecutive patients with DAH. The intrapulmonary administration of rFVIIa seemed to have a high benefit-to-risk ratio. Larger series should confirm the safety of this approach." @default.
- W1522782786 created "2016-06-24" @default.
- W1522782786 creator A5015807294 @default.
- W1522782786 creator A5034093405 @default.
- W1522782786 creator A5038678186 @default.
- W1522782786 creator A5052784704 @default.
- W1522782786 creator A5088006074 @default.
- W1522782786 date "2006-01-01" @default.
- W1522782786 modified "2023-10-18" @default.
- W1522782786 cites W1964654907 @default.
- W1522782786 cites W1970660789 @default.
- W1522782786 cites W1974095927 @default.
- W1522782786 cites W1980877232 @default.
- W1522782786 cites W2009505103 @default.
- W1522782786 cites W2025500567 @default.
- W1522782786 cites W2037875690 @default.
- W1522782786 cites W2039483996 @default.
- W1522782786 cites W2083212760 @default.
- W1522782786 cites W2087332566 @default.
- W1522782786 cites W2088776360 @default.
- W1522782786 cites W2099545643 @default.
- W1522782786 cites W2109839308 @default.
- W1522782786 cites W2114313929 @default.
- W1522782786 cites W2144380673 @default.
- W1522782786 cites W2166095184 @default.
- W1522782786 cites W2312238206 @default.
- W1522782786 cites W2509275080 @default.
- W1522782786 cites W4255335925 @default.
- W1522782786 doi "https://doi.org/10.1186/cc5132" @default.
- W1522782786 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1794493" @default.
- W1522782786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17184515" @default.
- W1522782786 hasPublicationYear "2006" @default.
- W1522782786 type Work @default.
- W1522782786 sameAs 1522782786 @default.
- W1522782786 citedByCount "90" @default.
- W1522782786 countsByYear W15227827862012 @default.
- W1522782786 countsByYear W15227827862013 @default.
- W1522782786 countsByYear W15227827862014 @default.
- W1522782786 countsByYear W15227827862015 @default.
- W1522782786 countsByYear W15227827862016 @default.
- W1522782786 countsByYear W15227827862017 @default.
- W1522782786 countsByYear W15227827862018 @default.
- W1522782786 countsByYear W15227827862019 @default.
- W1522782786 countsByYear W15227827862020 @default.
- W1522782786 countsByYear W15227827862021 @default.
- W1522782786 countsByYear W15227827862022 @default.
- W1522782786 countsByYear W15227827862023 @default.
- W1522782786 crossrefType "journal-article" @default.
- W1522782786 hasAuthorship W1522782786A5015807294 @default.
- W1522782786 hasAuthorship W1522782786A5034093405 @default.
- W1522782786 hasAuthorship W1522782786A5038678186 @default.
- W1522782786 hasAuthorship W1522782786A5052784704 @default.
- W1522782786 hasAuthorship W1522782786A5088006074 @default.
- W1522782786 hasBestOaLocation W15227827861 @default.
- W1522782786 hasConcept C126322002 @default.
- W1522782786 hasConcept C141071460 @default.
- W1522782786 hasConcept C2776376669 @default.
- W1522782786 hasConcept C2777408962 @default.
- W1522782786 hasConcept C2777714996 @default.
- W1522782786 hasConcept C2777961210 @default.
- W1522782786 hasConcept C2778589496 @default.
- W1522782786 hasConcept C2911091166 @default.
- W1522782786 hasConcept C42219234 @default.
- W1522782786 hasConcept C71924100 @default.
- W1522782786 hasConceptScore W1522782786C126322002 @default.
- W1522782786 hasConceptScore W1522782786C141071460 @default.
- W1522782786 hasConceptScore W1522782786C2776376669 @default.
- W1522782786 hasConceptScore W1522782786C2777408962 @default.
- W1522782786 hasConceptScore W1522782786C2777714996 @default.
- W1522782786 hasConceptScore W1522782786C2777961210 @default.
- W1522782786 hasConceptScore W1522782786C2778589496 @default.
- W1522782786 hasConceptScore W1522782786C2911091166 @default.
- W1522782786 hasConceptScore W1522782786C42219234 @default.
- W1522782786 hasConceptScore W1522782786C71924100 @default.
- W1522782786 hasIssue "6" @default.
- W1522782786 hasLocation W15227827861 @default.
- W1522782786 hasLocation W15227827862 @default.
- W1522782786 hasLocation W15227827863 @default.
- W1522782786 hasLocation W15227827864 @default.
- W1522782786 hasOpenAccess W1522782786 @default.
- W1522782786 hasPrimaryLocation W15227827861 @default.
- W1522782786 hasRelatedWork W2003938723 @default.
- W1522782786 hasRelatedWork W2047967234 @default.
- W1522782786 hasRelatedWork W2118496982 @default.
- W1522782786 hasRelatedWork W2364998975 @default.
- W1522782786 hasRelatedWork W2415138818 @default.
- W1522782786 hasRelatedWork W2439875401 @default.
- W1522782786 hasRelatedWork W2441567832 @default.
- W1522782786 hasRelatedWork W4238678312 @default.
- W1522782786 hasRelatedWork W4238867864 @default.
- W1522782786 hasRelatedWork W2525756941 @default.
- W1522782786 hasVolume "10" @default.
- W1522782786 isParatext "false" @default.
- W1522782786 isRetracted "false" @default.
- W1522782786 magId "1522782786" @default.
- W1522782786 workType "article" @default.